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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis

http://hdl.handle.net/10091/00020994
http://hdl.handle.net/10091/00020994
50e640b4-8b85-4d15-8266-7e162e4f3290
名前 / ファイル ライセンス アクション
3073504.pdf 3073504.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
言語 en
タイトル Genetic Contribution to the Pathogenesis of Primary Biliary Cholangitis
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Joshita, Satoru

× Joshita, Satoru

WEKO 106741

en Joshita, Satoru

Search repository
Umemura, Takeji

× Umemura, Takeji

WEKO 106742

en Umemura, Takeji

Search repository
Tanaka, Eiji

× Tanaka, Eiji

WEKO 106743

en Tanaka, Eiji

Search repository
Ota, Masao

× Ota, Masao

WEKO 106744

en Ota, Masao

Search repository
信州大学研究者総覧へのリンク
氏名 Umemura, Takeji
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html
出版者
出版者 HINDAWI LTD
引用
内容記述タイプ Other
内容記述 JOURNAL OF IMMUNOLOGY RESEARCH. :3073504(2017)
書誌情報 JOURNAL OF IMMUNOLOGY RESEARCH

p. 3073504, 発行日 2017-02-01
抄録
内容記述タイプ Abstract
内容記述 Formerly termed primary biliary cirrhosis, primary biliary cholangitis (PBC) is a chronic and progressive cholestatic liver disease characterized by the presence of antimitochondrial antibodies. Ursodeoxycholic acid (UDCA) therapy is the most effective and approved treatment for PBC and leads to a favorable outcome in the vast majority of cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades. Individuals in different geographic regions of the world may have varying susceptibility alleles that reflect indigenous triggering antigens. In this review, we describe the influence of HLA alleles and other gene polymorphisms on PBC along with the results of genome-wide association studies (GWAS) on this disease.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 2314-8861
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2017/3073504
関連名称 10.1155/2017/3073504
権利
権利情報 © 2017 Satoru Joshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000394871600001
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