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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth

http://hdl.handle.net/10091/00021007
91337dd1-1155-4c9f-a25e-6788a91244c2
名前 / ファイル ライセンス アクション
srep10554.pdf srep10554.pdf (1.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-10-31
タイトル
言語 en
タイトル The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth
言語
言語 eng
キーワード
主題Scheme Other
主題 Endocrinology
キーワード
主題Scheme Other
主題 Growth disorders
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakao, Kazumasa

× Nakao, Kazumasa

WEKO 106895

en Nakao, Kazumasa

Search repository
Osawa, Kenji

× Osawa, Kenji

WEKO 106896

en Osawa, Kenji

Search repository
Yasoda, Akihiro

× Yasoda, Akihiro

WEKO 106897

en Yasoda, Akihiro

Search repository
Yamanaka, Shigeki

× Yamanaka, Shigeki

WEKO 106898

en Yamanaka, Shigeki

Search repository
Fujii, Toshihito

× Fujii, Toshihito

WEKO 106899

en Fujii, Toshihito

Search repository
Kondo, Eri

× Kondo, Eri

WEKO 106900

en Kondo, Eri

Search repository
Koyama, Noriaki

× Koyama, Noriaki

WEKO 106901

en Koyama, Noriaki

Search repository
Kanamoto, Naotetsu

× Kanamoto, Naotetsu

WEKO 106902

en Kanamoto, Naotetsu

Search repository
Miura, Masako

× Miura, Masako

WEKO 106903

en Miura, Masako

Search repository
Kuwahara, Koichiro

× Kuwahara, Koichiro

WEKO 106904

en Kuwahara, Koichiro

Search repository
Akiyama, Haruhiko

× Akiyama, Haruhiko

WEKO 106905

en Akiyama, Haruhiko

Search repository
Bessho, Kazuhisa

× Bessho, Kazuhisa

WEKO 106906

en Bessho, Kazuhisa

Search repository
Nakao, Kazuwa

× Nakao, Kazuwa

WEKO 106907

en Nakao, Kazuwa

Search repository
信州大学研究者総覧へのリンク
氏名 Kuwahara, Koichiro
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HVchWCcp.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 5: 10554(2015)
書誌情報 SCIENTIFIC REPORTS

巻 5, p. 10554, 発行日 2015-05-27
抄録
内容記述タイプ Abstract
内容記述 Recent studies revealed C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of endochondral bone growth. As they exist ubiquitously in body, we investigated the physiological role of the local CNP/GC-B in the growth plate on bone growth using cartilage-specific knockout mice. Bones were severely shorter in cartilage-specific CNP or GC-B knockout mice and the extent was almost the same as that in respective systemic knockout mice. Cartilage-specific GC-B knockout mice were shorter than cartilage-specific CNP knockout mice. Hypertrophic chondrocyte layer of the growth plate was drastically reduced and proliferative chondrocyte layer, along with the proliferation of chondrocytes there, was moderately reduced in either cartilage-specific knockout mice. The survival rate of cartilage-specific CNP knockout mice was comparable to that of systemic CNP knockout mice. The local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth and might further affect mortality via unknown mechanisms.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/26014585
関連名称
関連名称 26014585
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep10554
関連名称
関連名称 10.1038/srep10554
権利
権利情報 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000355539800001
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