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Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway
http://hdl.handle.net/10091/00022481
http://hdl.handle.net/10091/000224817b258b65-dd49-406f-a416-35d9c72eab62
名前 / ファイル | ライセンス | アクション |
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ijms-18-02730.pdf (458.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3390/ijms18122730 | |||||
関連名称 | 10.3390/ijms18122730 | |||||
キーワード | ||||||
主題 | lysophospholipids, PPAR gamma, vascular diseases, dementia, spinal cord injury | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tsukahara, Tamotsu
× Tsukahara, Tamotsu× Matsuda, Yoshikazu× Haniu, Hisao |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Haniu, Hisao | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||
出版者 | ||||||
出版者 | MDPI | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18(12):2730 (2017) | |||||
書誌情報 |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻 18, 号 12, p. 2730, 発行日 2017-12 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The nuclear receptor superfamily includes ligand-inducible transcription factors that play diverse roles in cell metabolism and are associated with pathologies such as cardiovascular diseases. Lysophosphatidic acid (LPA) belongs to a family of lipid mediators. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and an intracellular nuclear hormone receptor. In addition, several enzymes that utilize LPA as a substrate or generate it as a product are under its regulatory control. Recent studies have demonstrated that the endogenously produced peroxisome proliferator-activated receptor gamma (PPAR gamma) antagonist cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPAR gamma function by stabilizing the binding of the co-repressor protein, a silencing mediator of retinoic acid, and the thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPAR gamma target gene transcription. The present review discusses the arbitrary aspects of the physiological and pathophysiological actions of lysophospholipids in vascular and nervous system biology. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1422-0067 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12038549 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/29258184 | |||||
関連名称 | 29258184 | |||||
権利 | ||||||
権利情報 | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000418896700232 |