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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway

http://hdl.handle.net/10091/00022481
7b258b65-dd49-406f-a416-35d9c72eab62
名前 / ファイル ライセンス アクション
ijms-18-02730.pdf ijms-18-02730.pdf (458.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-02-04
タイトル
言語 en
タイトル Lysophospholipid-Related Diseases and PPAR gamma Signaling Pathway
言語
言語 eng
キーワード
主題Scheme Other
主題 lysophospholipids
キーワード
主題Scheme Other
主題 PPAR gamma
キーワード
主題Scheme Other
主題 vascular diseases
キーワード
主題Scheme Other
主題 dementia
キーワード
主題Scheme Other
主題 spinal cord injury
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Tsukahara, Tamotsu

× Tsukahara, Tamotsu

WEKO 110109

en Tsukahara, Tamotsu

Search repository
Matsuda, Yoshikazu

× Matsuda, Yoshikazu

WEKO 110110

en Matsuda, Yoshikazu

Search repository
Haniu, Hisao

× Haniu, Hisao

WEKO 110111

en Haniu, Hisao

Search repository
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
出版者
出版者 MDPI
引用
内容記述タイプ Other
内容記述 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18(12):2730 (2017)
書誌情報 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

巻 18, 号 12, p. 2730, 発行日 2017-12
抄録
内容記述タイプ Abstract
内容記述 The nuclear receptor superfamily includes ligand-inducible transcription factors that play diverse roles in cell metabolism and are associated with pathologies such as cardiovascular diseases. Lysophosphatidic acid (LPA) belongs to a family of lipid mediators. LPA and its naturally occurring analogues interact with G protein-coupled receptors on the cell surface and an intracellular nuclear hormone receptor. In addition, several enzymes that utilize LPA as a substrate or generate it as a product are under its regulatory control. Recent studies have demonstrated that the endogenously produced peroxisome proliferator-activated receptor gamma (PPAR gamma) antagonist cyclic phosphatidic acid (cPA), which is structurally similar to LPA, inhibits cancer cell invasion and metastasis in vitro and in vivo. We recently observed that cPA negatively regulates PPAR gamma function by stabilizing the binding of the co-repressor protein, a silencing mediator of retinoic acid, and the thyroid hormone receptor. We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPAR gamma target gene transcription. The present review discusses the arbitrary aspects of the physiological and pathophysiological actions of lysophospholipids in vascular and nervous system biology.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 1422-0067
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12038549
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/29258184
関連名称
関連名称 29258184
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3390/ijms18122730
関連名称
関連名称 10.3390/ijms18122730
権利
権利情報 © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000418896700232
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