Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-02-04 |
タイトル |
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タイトル |
The AGP-PPAR gamma axis promotes oxidative stress and diabetic endothelial cell dysfunction |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.mce.2018.01.008 |
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関連名称 |
10.1016/j.mce.2018.01.008 |
キーワード |
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主題 |
Diabetes, eNOS, NO, Alkyl-glycerophosphate, PPAR gamma |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Tsukahara, Ryoko
Haniu, Hisao
Matsuda, Yoshikazu
Tsukahara, Tamotsu
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信州大学研究者総覧へのリンク |
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氏名 |
Haniu, Hisao |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
出版者 |
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出版者 |
ELSEVIER IRELAND LTD |
引用 |
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内容記述 |
MOLECULAR AND CELLULAR ENDOCRINOLOGY. 473:100-113 (2018) |
書誌情報 |
MOLECULAR AND CELLULAR ENDOCRINOLOGY
巻 473,
p. 100-113,
発行日 2018-09-15
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抄録 |
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内容記述 |
Alkyl-glycerophosphate (AGP) accumulates in atherogenic oxidized-LDL and human atherosclerotic plaques and is a potent agonist of peroxisome-proliferator-activated receptor-gamma (PPAR gamma). Recent studies suggest a potential regulatory role for PPAR gamma in endothelial nitric oxide synthase (eNOS) expression/activation and nitrogen oxide (NO) generation in the vascular endothelium. Importantly, eNOS-induced NO and advanced glycation end-products (AGEs) are involved in blood-vessel damage, and diabetic patients exhibit high serum NO and AGE levels; however, the effect of AGP on NO- and AGE-mediated endothelium dysfunction remains unknown. Investigation of the AGP-specific effects on NO- and AGE-mediated dysfunction and the underlying molecular mechanisms revealed that AGP upregulated eNOS expression and NO production, and that eNOS silencing and gamma antagonism inhibited AGP-mediated eNOS upregulation and NO production. Moreover, AGP-PPAR gamma-axis-mediated NO production promoted the generation of reactive oxygen species and AGE formation. These results suggested that AGP plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPAR gamma activation. (C) 2018 Elsevier B.V. All rights reserved. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0303-7207 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00745811 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/29355589 |
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関連名称 |
29355589 |
権利 |
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権利情報 |
©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000447981900010 |