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In Vitro and In Vivo Evaluation of Starfish Bone-Derived -Tricalcium Phosphate as a Bone Substitute Material
http://hdl.handle.net/10091/00022484
http://hdl.handle.net/10091/0002248478ba019c-c112-4660-ad91-794f9a59bd7e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
materials-12-01881.pdf (10.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||
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| 公開日 | 2021-02-04 | |||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||
| タイトル | In Vitro and In Vivo Evaluation of Starfish Bone-Derived -Tricalcium Phosphate as a Bone Substitute Material | |||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3390/ma12111881 | |||||||||||||||||||||||||
| 関連名称 | 10.3390/ma12111881 | |||||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||||
| 主題 | starfish, calcium carbonate, porous calcium phosphate, #NAME?, bone substitute, angiogenesis | |||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||
| 著者 |
Ishida, Haruka
× Ishida, Haruka
× Haniu, Hisao
× Takeuchi, Akari
× Ueda, Katsuya
× Sano, Mahoko
× Tanaka, Manabu
× Takizawa, Takashi
× Sobajima, Atsushi
× Kamanaka, Takayuki
× Saito, Naoto
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| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Haniu, Hisao | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html | |||||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Takeuchi, Akari | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gaSCWVDV.html | |||||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Takizawa, Takashi | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html | |||||||||||||||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||||||||||||||
| 氏名 | Saito, Naoto | |||||||||||||||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html | |||||||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||||||
| 出版者 | MDPI | |||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||
| 内容記述 | MATERIALS. 12(11):1881 (2019) | |||||||||||||||||||||||||
| 書誌情報 |
MATERIALS 巻 12, 号 11, p. 1881, 発行日 2019-06-01 |
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| 抄録 | ||||||||||||||||||||||||||
| 内容記述 | We evaluated starfish-derived -tricalcium phosphate (Sf-TCP) obtained by phosphatization of starfish-bone-derived porous calcium carbonate as a potential bone substitute material. The Sf-TCP had a communicating pore structure with a pore size of approximately 10 m. Although the porosity of Sf-TCP was similar to that of Cerasorb M (CM)a commercially available -TCP bone fillerthe specific surface area was roughly three times larger than that of CM. Observation by scanning electron microscopy showed that pores communicated to the inside of the Sf-TCP. Cell growth tests showed that Sf-TCP improved cell proliferation compared with CM. Cells grown on Sf-TCP showed stretched filopodia and adhered; cells migrated both to the surface and into pores. In vivo, vigorous tissue invasion into pores was observed in Sf-TCP, and more fibrous tissue was observed for Sf-TCP than CM. Moreover, capillary formation into pores was observed for Sf-TCP. Thus, Sf-TCP showed excellent biocompatibility in vitro and more vigorous bone formation in vivo, indicating the possible applications of this material as a bone substitute. In addition, our findings suggested that mimicking the microstructure derived from whole organisms may facilitate the development of superior artificial bone. | |||||||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||||||
| 収録物識別子 | 1996-1944 | |||||||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||||||
| 識別子タイプ | NCID | |||||||||||||||||||||||||
| 関連識別子 | BB25053562 | |||||||||||||||||||||||||
| 権利 | ||||||||||||||||||||||||||
| 権利情報 | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||||
| WoS | ||||||||||||||||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000472638600155 | |||||||||||||||||||||||||
