| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-02-04 |
| タイトル |
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タイトル |
In Vitro and In Vivo Evaluation of Starfish Bone-Derived -Tricalcium Phosphate as a Bone Substitute Material |
| 言語 |
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|
言語 |
eng |
| DOI |
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|
関連識別子 |
https://doi.org/10.3390/ma12111881 |
|
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関連名称 |
10.3390/ma12111881 |
| キーワード |
|
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主題 |
starfish, calcium carbonate, porous calcium phosphate, #NAME?, bone substitute, angiogenesis |
| 資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Ishida, Haruka
Haniu, Hisao
Takeuchi, Akari
Ueda, Katsuya
Sano, Mahoko
Tanaka, Manabu
Takizawa, Takashi
Sobajima, Atsushi
Kamanaka, Takayuki
Saito, Naoto
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Haniu, Hisao |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Takeuchi, Akari |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gaSCWVDV.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Takizawa, Takashi |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OhTebVym.html |
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Saito, Naoto |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html |
| 出版者 |
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出版者 |
MDPI |
| 引用 |
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内容記述 |
MATERIALS. 12(11):1881 (2019) |
| 書誌情報 |
MATERIALS
巻 12,
号 11,
p. 1881,
発行日 2019-06-01
|
| 抄録 |
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内容記述 |
We evaluated starfish-derived -tricalcium phosphate (Sf-TCP) obtained by phosphatization of starfish-bone-derived porous calcium carbonate as a potential bone substitute material. The Sf-TCP had a communicating pore structure with a pore size of approximately 10 m. Although the porosity of Sf-TCP was similar to that of Cerasorb M (CM)a commercially available -TCP bone fillerthe specific surface area was roughly three times larger than that of CM. Observation by scanning electron microscopy showed that pores communicated to the inside of the Sf-TCP. Cell growth tests showed that Sf-TCP improved cell proliferation compared with CM. Cells grown on Sf-TCP showed stretched filopodia and adhered; cells migrated both to the surface and into pores. In vivo, vigorous tissue invasion into pores was observed in Sf-TCP, and more fibrous tissue was observed for Sf-TCP than CM. Moreover, capillary formation into pores was observed for Sf-TCP. Thus, Sf-TCP showed excellent biocompatibility in vitro and more vigorous bone formation in vivo, indicating the possible applications of this material as a bone substitute. In addition, our findings suggested that mimicking the microstructure derived from whole organisms may facilitate the development of superior artificial bone. |
| 資源タイプ（コンテンツの種類） |
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1996-1944 |
| 書誌レコードID |
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識別子タイプ |
NCID |
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関連識別子 |
BB25053562 |
| 権利 |
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権利情報 |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 出版タイプ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| WoS |
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|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000472638600155 |
materials-12-01881.pdf (10.8 MB)
