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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice

http://hdl.handle.net/10091/18189
2faf0300-d8e8-4cf1-90fb-9d64ecbc0cf4
名前 / ファイル ライセンス アクション
Carcinogenicity_evaluation.pdf Carcinogenicity_evaluation.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-04-06
タイトル
言語 en
タイトル Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Takanashi, Seiji

× Takanashi, Seiji

WEKO 6154

en Takanashi, Seiji

Search repository
Hara, Kazuo

× Hara, Kazuo

WEKO 6155

en Hara, Kazuo

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Aoki, Kaoru

× Aoki, Kaoru

WEKO 6156

en Aoki, Kaoru

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Usui, Yuki

× Usui, Yuki

WEKO 6157

en Usui, Yuki

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Shimizu, Masayuki

× Shimizu, Masayuki

WEKO 6158

en Shimizu, Masayuki

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Haniu, Hisao

× Haniu, Hisao

WEKO 6159

en Haniu, Hisao

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Ogihara, Nobuhide

× Ogihara, Nobuhide

WEKO 6160

en Ogihara, Nobuhide

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Ishigaki, Norio

× Ishigaki, Norio

WEKO 6161

en Ishigaki, Norio

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Nakamura, Koichi

× Nakamura, Koichi

WEKO 6162

en Nakamura, Koichi

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Okamoto, Masanori

× Okamoto, Masanori

WEKO 6163

en Okamoto, Masanori

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Kobayashi, Shinsuke

× Kobayashi, Shinsuke

WEKO 6164

en Kobayashi, Shinsuke

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Kato, Hiroyuki

× Kato, Hiroyuki

WEKO 6165

en Kato, Hiroyuki

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Sano, Kenji

× Sano, Kenji

WEKO 6166

en Sano, Kenji

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Nishimura, Naoyuki

× Nishimura, Naoyuki

WEKO 6167

en Nishimura, Naoyuki

Search repository
Tsutsumi, Hideki

× Tsutsumi, Hideki

WEKO 6168

en Tsutsumi, Hideki

Search repository
Machida, Kazuhiko

× Machida, Kazuhiko

WEKO 6169

en Machida, Kazuhiko

Search repository
Saito, Naoto

× Saito, Naoto

WEKO 6170

en Saito, Naoto

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信州大学研究者総覧へのリンク
氏名 Aoki, Kaoru
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeDpbhym.html
信州大学研究者総覧へのリンク
氏名 Haniu, Hisao
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jakpPmSa.html
信州大学研究者総覧へのリンク
氏名 Okamoto, Masanori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uafabVym.html
信州大学研究者総覧へのリンク
氏名 Kato, Hiroyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WVkCbaSp.html
信州大学研究者総覧へのリンク
氏名 Saito, Naoto
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WpkhuUkh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 SCIENTIFIC REPORTS. 2:498 (2012)
書誌情報 SCIENTIFIC REPORTS

巻 2, p. 498, 発行日 2012-07-09
抄録
内容記述タイプ Abstract
内容記述 The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations, carcinogenicity should be examined with the highest priority; however, no report using transgenic mice to evaluate the carcinogenicity of CNTs has been published to date. Here, we performed a carcinogenicity test by implanting multi-walled CNTs (MWCNTs) into the subcutaneous tissue of rasH2 mice, using the carbon black present in black tattoo ink as a reference material for safety. The rasH2 mice did not develop neoplasms after being injected with MWCNTs; instead, MWCNTs showed lower carcinogenicity than carbon black. Such evaluations should facilitate the clinical application and development of CNTs for use in important medical fields.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/22787556
関連名称
関連名称 22787556
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep00498
関連名称
関連名称 10.1038/srep00498
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000306179000001
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