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AGM-S3 cells in concert with stem cell factor plus thrombopoietin increased the numbers of peripheral blood CD34(+) cells to approximately 20-fold of the input value after 2 weeks in nine JMML patients with either PTPN11 mutations or RAS mutations, who received allogeneic hematopoietic transplantation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) also augmented the proliferation of JMML CD34(+) cells on AGM-S3 cells. The expansion potential of CD34(+) cells was markedly low in four patients who achieved spontaneous hematological improvement. A large proportion of day-14-cultured CD34(+) cells were negative for CD38 and cryopreservable. Cultured JMML CD34(+)CD38(-) cells expressed CD117, CD116, c-mpl, CD123, CD90, but not CXCR4, and formed GM and erythroid colonies. Day-7-cultured CD34(+) cells from two of three JMML patients injected intrafemorally into immunodeficient mice stimulated with human GM-CSF after transplantation displayed significant hematopoietic reconstitution. The abilities of OP9 cells and MS-5 cells were one-third and one-tenth, respectively, of the value obtained with AGM-S3 cells. 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on AGM-S3 cells in juvenile myelomonocytic leukemia"], "weko_shared_id": -1}
  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia

http://hdl.handle.net/10091/18010
http://hdl.handle.net/10091/18010
0ad2096e-b98c-4f96-aceb-5999e164aa9d
名前 / ファイル ライセンス アクション
In_vitro_expansion_of_CD34+CD38-_cells.pdf In_vitro_expansion_of_CD34+CD38-_cells.pdf (1.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-01-06
タイトル
言語 en
タイトル In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sakashita, Kazuo

× Sakashita, Kazuo

WEKO 6195

en Sakashita, Kazuo

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Kato, Itaru

× Kato, Itaru

WEKO 6196

en Kato, Itaru

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Daifu, Tomoo

× Daifu, Tomoo

WEKO 6197

en Daifu, Tomoo

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Saida, Satoshi

× Saida, Satoshi

WEKO 6198

en Saida, Satoshi

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Hiramatsu, Hidefumi

× Hiramatsu, Hidefumi

WEKO 6199

en Hiramatsu, Hidefumi

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Nishinaka, Yoko

× Nishinaka, Yoko

WEKO 6200

en Nishinaka, Yoko

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Ebihara, Yasuhiro

× Ebihara, Yasuhiro

WEKO 6201

en Ebihara, Yasuhiro

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Ma, Feng

× Ma, Feng

WEKO 6202

en Ma, Feng

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Matsuda, Kazuyuki

× Matsuda, Kazuyuki

WEKO 6203

en Matsuda, Kazuyuki

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Saito, Shoji

× Saito, Shoji

WEKO 6204

en Saito, Shoji

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Hirabayashi, Koichi

× Hirabayashi, Koichi

WEKO 6205

en Hirabayashi, Koichi

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Kurata, Takashi

× Kurata, Takashi

WEKO 6206

en Kurata, Takashi

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Uyen, Le Thanh Nha

× Uyen, Le Thanh Nha

WEKO 6207

en Uyen, Le Thanh Nha

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Nakazawa, Yozo

× Nakazawa, Yozo

WEKO 6208

en Nakazawa, Yozo

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Tsuji, Kohichiro

× Tsuji, Kohichiro

WEKO 6209

en Tsuji, Kohichiro

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Heike, Toshio

× Heike, Toshio

WEKO 6210

en Heike, Toshio

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Nakahata, Tatsutoshi

× Nakahata, Tatsutoshi

WEKO 6211

en Nakahata, Tatsutoshi

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Koike, Kenichi

× Koike, Kenichi

WEKO 6212

en Koike, Kenichi

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信州大学研究者総覧へのリンク
氏名 Nakazawa, Yozo
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 LEUKEMIA. 29(3):606-614 (2015)<br/>
書誌情報 LEUKEMIA

巻 29, 号 3, p. 606-614, 発行日 2015
内容記述
内容記述タイプ Other
内容記述 advance online publication, August 8, 2014 [Epub ahead of print]
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0887-6924
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/25102944
関連名称 25102944
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/leu.2014.239
関連名称 10.1038/leu.2014.239
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000350734300010
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