{"_buckets": {"deposit": "157bf650-cfa5-4e7f-af53-5b1f08e95c62"}, "_deposit": {"id": "3671", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3671"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003671", "sets": ["462"]}, "author_link": ["6195", "6196", "6197", "6198", "6199", "6200", "6201", "6202", "6203", "6204", "6205", "6206", "6207", "6208", "6209", "6210", "6211", "6212"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "614", "bibliographicPageStart": "606", "bibliographicVolumeNumber": "29", "bibliographic_titles": [{"bibliographic_title": "LEUKEMIA"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "advance online publication, August 8, 2014 [Epub ahead of print]", "subitem_description_type": "Other"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "LEUKEMIA. 29(3):606-614 (2015)\u003cbr/\u003e", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Nakazawa, Yozo", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000350734300010"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "NATURE PUBLISHING GROUP"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "25102944"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/25102944", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/leu.2014.239"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/leu.2014.239", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0887-6924", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0887-6924", "subitem_source_identifier_type": "PISSN"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "CHRONIC MYELOGENOUS LEUKEMIA; STEM-CELLS; RAS MUTATIONS; SCID MICE; THROMBOPOIETIN; REPOPULATION; PATHOGENESIS; IMPROVEMENT; MOUSE; MODEL"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Using serum-containing culture, we examined whether AGM-S3 stromal cells, alone or in combination with hematopoietic growth factor(s), stimulated the proliferation of CD34(+) cells from patients with juvenile myelomonocytic leukemia (JMML). AGM-S3 cells in concert with stem cell factor plus thrombopoietin increased the numbers of peripheral blood CD34(+) cells to approximately 20-fold of the input value after 2 weeks in nine JMML patients with either PTPN11 mutations or RAS mutations, who received allogeneic hematopoietic transplantation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) also augmented the proliferation of JMML CD34(+) cells on AGM-S3 cells. The expansion potential of CD34(+) cells was markedly low in four patients who achieved spontaneous hematological improvement. A large proportion of day-14-cultured CD34(+) cells were negative for CD38 and cryopreservable. Cultured JMML CD34(+)CD38(-) cells expressed CD117, CD116, c-mpl, CD123, CD90, but not CXCR4, and formed GM and erythroid colonies. Day-7-cultured CD34(+) cells from two of three JMML patients injected intrafemorally into immunodeficient mice stimulated with human GM-CSF after transplantation displayed significant hematopoietic reconstitution. The abilities of OP9 cells and MS-5 cells were one-third and one-tenth, respectively, of the value obtained with AGM-S3 cells. Our culture system may provide a useful tool for elucidating leukemogenesis and for therapeutic approaches in JMML."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sakashita,  Kazuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato,  Itaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Daifu,  Tomoo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saida,  Satoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiramatsu,  Hidefumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishinaka,  Yoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ebihara,  Yasuhiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ma,  Feng", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda,  Kazuyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito,  Shoji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirabayashi,  Koichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6205", "nameIdentifierScheme": 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{"creatorNames": [{"creatorName": "Koike,  Kenichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "6212", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "In_vitro_expansion_of_CD34+CD38-_cells.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "In_vitro_expansion_of_CD34+CD38-_cells.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3671/files/In_vitro_expansion_of_CD34+CD38-_cells.pdf"}, "version_id": "6d208ec8-6a3e-448e-82fb-21240c7b7389"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, 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