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AGM-S3 cells in concert with stem cell factor plus thrombopoietin increased the numbers of peripheral blood CD34(+) cells to approximately 20-fold of the input value after 2 weeks in nine JMML patients with either PTPN11 mutations or RAS mutations, who received allogeneic hematopoietic transplantation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) also augmented the proliferation of JMML CD34(+) cells on AGM-S3 cells. The expansion potential of CD34(+) cells was markedly low in four patients who achieved spontaneous hematological improvement. A large proportion of day-14-cultured CD34(+) cells were negative for CD38 and cryopreservable. Cultured JMML CD34(+)CD38(-) cells expressed CD117, CD116, c-mpl, CD123, CD90, but not CXCR4, and formed GM and erythroid colonies. Day-7-cultured CD34(+) cells from two of three JMML patients injected intrafemorally into immunodeficient mice stimulated with human GM-CSF after transplantation displayed significant hematopoietic reconstitution. The abilities of OP9 cells and MS-5 cells were one-third and one-tenth, respectively, of the value obtained with AGM-S3 cells. 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In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia
http://hdl.handle.net/10091/18010
http://hdl.handle.net/10091/180100ad2096e-b98c-4f96-aceb-5999e164aa9d
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-01-06 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sakashita, Kazuo
× Sakashita, Kazuo× Kato, Itaru× Daifu, Tomoo× Saida, Satoshi× Hiramatsu, Hidefumi× Nishinaka, Yoko× Ebihara, Yasuhiro× Ma, Feng× Matsuda, Kazuyuki× Saito, Shoji× Hirabayashi, Koichi× Kurata, Takashi× Uyen, Le Thanh Nha× Nakazawa, Yozo× Tsuji, Kohichiro× Heike, Toshio× Nakahata, Tatsutoshi× Koike, Kenichi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nakazawa, Yozo | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html | |||||
出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | LEUKEMIA. 29(3):606-614 (2015)<br/> | |||||
書誌情報 |
LEUKEMIA 巻 29, 号 3, p. 606-614, 発行日 2015 |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | advance online publication, August 8, 2014 [Epub ahead of print] | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0887-6924 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/25102944 | |||||
関連名称 | 25102944 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/leu.2014.239 | |||||
関連名称 | 10.1038/leu.2014.239 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000350734300010 |