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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform

http://hdl.handle.net/10091/17837
4524375e-93ea-4393-8fe3-d53a0b2eae3c
名前 / ファイル ライセンス アクション
AA_amyloidosis-resistant_CE_J_mice.pdf AA_amyloidosis-resistant_CE_J_mice.pdf (696.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-09-05
タイトル
言語 en
タイトル AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
言語
言語 eng
キーワード
主題Scheme Other
主題 Amino acid substitution
キーワード
主題Scheme Other
主題 gene conversion
キーワード
主題Scheme Other
主題 gene family
キーワード
主題Scheme Other
主題 mouse strain
キーワード
主題Scheme Other
主題 nucleotide substitution
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Mori, Masayuki

× Mori, Masayuki

WEKO 6248

en Mori, Masayuki

Search repository
Tiang, Geng

× Tiang, Geng

WEKO 6249

en Tiang, Geng

Search repository
Higuchi, Keiichi

× Higuchi, Keiichi

WEKO 6250

en Higuchi, Keiichi

Search repository
信州大学研究者総覧へのリンク
氏名 Mori, Masayuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html
信州大学研究者総覧へのリンク
氏名 Higuchi, Keiichi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html
出版者
出版者 INFORMA HEALTHCARE
引用
内容記述タイプ Other
内容記述 AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 21(1):1-8 (2014)
書誌情報 AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

巻 21, 号 1, p. 1-8, 発行日 2014-03
抄録
内容記述タイプ Abstract
内容記述 The CE/J mouse strain is resistant to amyloid A protein (AA) amyloidosis. In contrast to AA amyloidosis-susceptible mouse strains that concomitantly express serum amyloid A precursor protein (SAA) types 1 and 2 isoforms encoded by the Saa1 and Saa2 genes, respectively, in response to inflammatory stimulation from the liver, CE/J mice express only a single SAA isoform named SAA2.2. In addition, CE/J mice uniquely possess a Q30L amino acid substitution in SAA2.2 that inhibits amyloidogenesis. To elucidate the genetic basis underlying the expression of only a single SAA isoform in this strain, we conducted PCR cloning and nucleotide sequencing of the Saa1 and Saa2 genes from the CE/J genome. We revealed that CE/J mice possess functional Saa1 and Saa2 genes. Intriguingly, the two genes were identical with respect to amino acid sequence, each encoding the SAA2.2 isoform. RT-PCR analysis of inflamed liver tissue from CE/J mice demonstrated that both genes are expressed at equivalent levels. Reporter assays revealed that promoter/enhancer sequences of Saa1 and Saa2 genes in CE/J are also functional. These results indicate that the SAA2.2 isoform in CE/J is a mixture of Saa1 and Saa2 gene products.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1350-6129
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11096426
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/24228751
関連名称
関連名称 24228751
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3109/13506129.2013.852529
関連名称
関連名称 10.3109/13506129.2013.852529
権利
権利情報 Copyright© 2014 Informa Healthcare
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000335764200001
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