Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-09-05 |
タイトル |
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タイトル |
AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.3109/13506129.2013.852529 |
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関連名称 |
10.3109/13506129.2013.852529 |
キーワード |
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主題 |
Amino acid substitution, gene conversion, gene family, mouse strain, nucleotide substitution |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Mori, Masayuki
Tiang, Geng
Higuchi, Keiichi
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信州大学研究者総覧へのリンク |
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氏名 |
Mori, Masayuki |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html |
信州大学研究者総覧へのリンク |
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氏名 |
Higuchi, Keiichi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html |
出版者 |
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出版者 |
INFORMA HEALTHCARE |
引用 |
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内容記述 |
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 21(1):1-8 (2014) |
書誌情報 |
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
巻 21,
号 1,
p. 1-8,
発行日 2014-03
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抄録 |
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内容記述 |
The CE/J mouse strain is resistant to amyloid A protein (AA) amyloidosis. In contrast to AA amyloidosis-susceptible mouse strains that concomitantly express serum amyloid A precursor protein (SAA) types 1 and 2 isoforms encoded by the Saa1 and Saa2 genes, respectively, in response to inflammatory stimulation from the liver, CE/J mice express only a single SAA isoform named SAA2.2. In addition, CE/J mice uniquely possess a Q30L amino acid substitution in SAA2.2 that inhibits amyloidogenesis. To elucidate the genetic basis underlying the expression of only a single SAA isoform in this strain, we conducted PCR cloning and nucleotide sequencing of the Saa1 and Saa2 genes from the CE/J genome. We revealed that CE/J mice possess functional Saa1 and Saa2 genes. Intriguingly, the two genes were identical with respect to amino acid sequence, each encoding the SAA2.2 isoform. RT-PCR analysis of inflamed liver tissue from CE/J mice demonstrated that both genes are expressed at equivalent levels. Reporter assays revealed that promoter/enhancer sequences of Saa1 and Saa2 genes in CE/J are also functional. These results indicate that the SAA2.2 isoform in CE/J is a mixture of Saa1 and Saa2 gene products. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1350-6129 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11096426 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/24228751 |
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関連名称 |
24228751 |
権利 |
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権利情報 |
Copyright© 2014 Informa Healthcare |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000335764200001 |