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AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
http://hdl.handle.net/10091/17837
http://hdl.handle.net/10091/178374524375e-93ea-4393-8fe3-d53a0b2eae3c
| 名前 / ファイル | ライセンス | アクション |
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AA_amyloidosis-resistant_CE_J_mice.pdf (696.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2014-09-05 | |||||||||||
| タイトル | ||||||||||||
| タイトル | AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.3109/13506129.2013.852529 | |||||||||||
| 関連名称 | 10.3109/13506129.2013.852529 | |||||||||||
| キーワード | ||||||||||||
| 主題 | Amino acid substitution, gene conversion, gene family, mouse strain, nucleotide substitution | |||||||||||
| 資源タイプ | ||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| タイプ | journal article | |||||||||||
| 著者 |
Mori, Masayuki
× Mori, Masayuki
× Tiang, Geng
× Higuchi, Keiichi
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| 信州大学研究者総覧へのリンク | ||||||||||||
| 氏名 | Mori, Masayuki | |||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OpSCZafV.html | |||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||
| 氏名 | Higuchi, Keiichi | |||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | INFORMA HEALTHCARE | |||||||||||
| 引用 | ||||||||||||
| 内容記述 | AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 21(1):1-8 (2014) | |||||||||||
| 書誌情報 |
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 巻 21, 号 1, p. 1-8, 発行日 2014-03 |
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| 抄録 | ||||||||||||
| 内容記述 | The CE/J mouse strain is resistant to amyloid A protein (AA) amyloidosis. In contrast to AA amyloidosis-susceptible mouse strains that concomitantly express serum amyloid A precursor protein (SAA) types 1 and 2 isoforms encoded by the Saa1 and Saa2 genes, respectively, in response to inflammatory stimulation from the liver, CE/J mice express only a single SAA isoform named SAA2.2. In addition, CE/J mice uniquely possess a Q30L amino acid substitution in SAA2.2 that inhibits amyloidogenesis. To elucidate the genetic basis underlying the expression of only a single SAA isoform in this strain, we conducted PCR cloning and nucleotide sequencing of the Saa1 and Saa2 genes from the CE/J genome. We revealed that CE/J mice possess functional Saa1 and Saa2 genes. Intriguingly, the two genes were identical with respect to amino acid sequence, each encoding the SAA2.2 isoform. RT-PCR analysis of inflamed liver tissue from CE/J mice demonstrated that both genes are expressed at equivalent levels. Reporter assays revealed that promoter/enhancer sequences of Saa1 and Saa2 genes in CE/J are also functional. These results indicate that the SAA2.2 isoform in CE/J is a mixture of Saa1 and Saa2 gene products. | |||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1350-6129 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA11096426 | |||||||||||
| PubMed | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24228751 | |||||||||||
| 関連名称 | 24228751 | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright© 2014 Informa Healthcare | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| WoS | ||||||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000335764200001 | |||||||||||
