{"_buckets": {"deposit": "62fa1587-8117-4a48-8eba-4f47ea1fdee7"}, "_deposit": {"id": "3691", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3691"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003691"}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "616", "bibliographicPageStart": "613", "bibliographicVolumeNumber": "56", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF HUMAN GENETICS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (\u003e= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. 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A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (\u003e= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasayama,  Daimei"}], "nameIdentifiers": [{"nameIdentifier": "6364", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hori,  Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "6365", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teraishi,  Toshiya"}], "nameIdentifiers": [{"nameIdentifier": "6366", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hattori,  Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "6367", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  Miho"}], "nameIdentifiers": [{"nameIdentifier": "6368", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo,  Junko"}], "nameIdentifiers": [{"nameIdentifier": "6369", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamoto,  Yumiko"}], "nameIdentifiers": [{"nameIdentifier": "6370", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kinoshita,  Yukiko"}], "nameIdentifiers": [{"nameIdentifier": "6371", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi,  Teruhiko"}], "nameIdentifiers": [{"nameIdentifier": "6372", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano,  Naoji"}], "nameIdentifiers": [{"nameIdentifier": "6373", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunugi,  Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "6374", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Association_interleukin-1beta_genetic_polymorphisms.pdf", "filesize": [{"value": "345.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 345100.0, "url": {"label": "Association_interleukin-1beta_genetic_polymorphisms.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3691/files/Association_interleukin-1beta_genetic_polymorphisms.pdf"}, "version_id": "14bbaf44-74f3-4ee4-aaf3-aa418b3c9a89"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "cognitive function", "subitem_subject_scheme": "Other"}, {"subitem_subject": "genetic polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "interleukin-1 beta", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intelligence", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17724", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2014-07-23"}, "publish_date": "2014-07-23", "publish_status": "0", "recid": "3691", "relation": {}, "relation_version_is_last": true, "title": ["Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia"], "weko_shared_id": null}