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Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia
http://hdl.handle.net/10091/17724
http://hdl.handle.net/10091/1772495ba7465-3b66-40ab-b330-ddd16b9f89c6
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-07-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cognitive function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | genetic polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interleukin-1 beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intelligence | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sasayama, Daimei
× Sasayama, Daimei× Hori, Hiroaki× Teraishi, Toshiya× Hattori, Kotaro× Ota, Miho× Matsuo, Junko× Kawamoto, Yumiko× Kinoshita, Yukiko× Higuchi, Teruhiko× Amano, Naoji× Kunugi, Hiroshi |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Sasayama, Daimei | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html | |||||
出版者 | ||||||
出版者 | NATURE PUBLISHING GROUP | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF HUMAN GENETICS. 56(8):613-616 (2011) | |||||
書誌情報 |
JOURNAL OF HUMAN GENETICS 巻 56, 号 8, p. 613-616, 発行日 2011-08 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (>= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011 | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1434-5161 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11206160 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21614008 | |||||
関連名称 | 21614008 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/jhg.2011.56 | |||||
関連名称 | 10.1038/jhg.2011.56 | |||||
権利 | ||||||
権利情報 | Copyright© 2011 The Japan Society of Human Genetics | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294246100013 |