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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia

http://hdl.handle.net/10091/17724
http://hdl.handle.net/10091/17724
95ba7465-3b66-40ab-b330-ddd16b9f89c6
名前 / ファイル ライセンス アクション
Association_interleukin-1beta_genetic_polymorphisms.pdf Association_interleukin-1beta_genetic_polymorphisms.pdf (345.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-07-23
タイトル
言語 en
タイトル Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia
言語
言語 eng
キーワード
主題Scheme Other
主題 cognitive function
キーワード
主題Scheme Other
主題 genetic polymorphism
キーワード
主題Scheme Other
主題 interleukin-1 beta
キーワード
主題Scheme Other
主題 intelligence
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

WEKO 6364

en Sasayama, Daimei

Search repository
Hori, Hiroaki

× Hori, Hiroaki

WEKO 6365

en Hori, Hiroaki

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Teraishi, Toshiya

× Teraishi, Toshiya

WEKO 6366

en Teraishi, Toshiya

Search repository
Hattori, Kotaro

× Hattori, Kotaro

WEKO 6367

en Hattori, Kotaro

Search repository
Ota, Miho

× Ota, Miho

WEKO 6368

en Ota, Miho

Search repository
Matsuo, Junko

× Matsuo, Junko

WEKO 6369

en Matsuo, Junko

Search repository
Kawamoto, Yumiko

× Kawamoto, Yumiko

WEKO 6370

en Kawamoto, Yumiko

Search repository
Kinoshita, Yukiko

× Kinoshita, Yukiko

WEKO 6371

en Kinoshita, Yukiko

Search repository
Higuchi, Teruhiko

× Higuchi, Teruhiko

WEKO 6372

en Higuchi, Teruhiko

Search repository
Amano, Naoji

× Amano, Naoji

WEKO 6373

en Amano, Naoji

Search repository
Kunugi, Hiroshi

× Kunugi, Hiroshi

WEKO 6374

en Kunugi, Hiroshi

Search repository
信州大学研究者総覧へのリンク
氏名 Sasayama, Daimei
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html
出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述タイプ Other
内容記述 JOURNAL OF HUMAN GENETICS. 56(8):613-616 (2011)
書誌情報 JOURNAL OF HUMAN GENETICS

巻 56, 号 8, p. 613-616, 発行日 2011-08
抄録
内容記述タイプ Abstract
内容記述 Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (>= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1434-5161
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11206160
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21614008
関連名称 21614008
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/jhg.2011.56
関連名称 10.1038/jhg.2011.56
権利
権利情報 Copyright© 2011 The Japan Society of Human Genetics
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294246100013
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