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Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia
http://hdl.handle.net/10091/17724
http://hdl.handle.net/10091/1772495ba7465-3b66-40ab-b330-ddd16b9f89c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Association_interleukin-1beta_genetic_polymorphisms.pdf (345.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-23 | |||||
| タイトル | ||||||
| タイトル | Association of interleukin-1 beta genetic polymorphisms with cognitive performance in elderly females without dementia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/jhg.2011.56 | |||||
| 関連名称 | 10.1038/jhg.2011.56 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cognitive function | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | genetic polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | interleukin-1 beta | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intelligence | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Sasayama, Daimei
× Sasayama, Daimei× Hori, Hiroaki× Teraishi, Toshiya× Hattori, Kotaro× Ota, Miho× Matsuo, Junko× Kawamoto, Yumiko× Kinoshita, Yukiko× Higuchi, Teruhiko× Amano, Naoji× Kunugi, Hiroshi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Sasayama, Daimei | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html | |||||
| 出版者 | ||||||
| 出版者 | NATURE PUBLISHING GROUP | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | JOURNAL OF HUMAN GENETICS. 56(8):613-616 (2011) | |||||
| 書誌情報 |
JOURNAL OF HUMAN GENETICS 巻 56, 号 8, p. 613-616, 発行日 2011-08 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin-1 beta (IL-1 beta) is considered to have a role in age-related cognitive decline. A recent study has shown that a promoter polymorphism of the IL-1 beta gene (rs16944) is associated with cognitive performance in elderly males without dementia. In this study, we examined whether polymorphisms of the IL-1 beta gene also influence cognitive functions in elderly females. Cognitive functions were assessed by the Wechsler adult intelligence scale-revised (WAIS-R) in 99 elderly (>= 60 years) females without dementia. We selected five tagging polymorphisms from the IL-1 beta gene and examined the associations with the WAIS-R scores. Significant associations were found between verbal intelligence quotient (IQ) and the genotypes of rs1143634 and rs1143633 (P = 0.0037 and P = 0.010, respectively). No significant associations of rs16944 genotype were found with verbal or performance IQ. However, individuals homozygous for the G allele of rs16944 achieved higher scores in digit span compared with their counterpart, which is consistent with the previous findings in males. These results suggest that IL-1 beta gene variation may have a role in cognitive functions in aging females as well as males. Journal of Human Genetics (2011) 56, 613-616; doi:10.1038/jhg.2011.56; published online 26 May 2011 | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1434-5161 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11206160 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21614008 | |||||
| 関連名称 | 21614008 | |||||
| 権利 | ||||||
| 権利情報 | Copyright© 2011 The Japan Society of Human Genetics | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000294246100013 | |||||
