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Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF NEURAL TRANSMISSION. 119(3):313-318 (2012)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Sasayama, Daimei", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.uNkegpkh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000300587900002"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "SPRINGER WIEN"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21879314"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21879314", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00702-011-0709-3"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1007/s00702-011-0709-3", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The original publication is available at www.springerlink.com"}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0300-9564", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0300-9564", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11077137", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "Cognitive function; Interleukin-6; Genetic polymorphism; Intelligence"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; LONG-TERM POTENTIATION; TRANSGENIC MICE; IL-6R GENE; DSM-IV; MINI; CYTOKINES; DECLINE; DISEASE; PROTEIN"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Sasayama,  Daimei"}], "nameIdentifiers": [{"nameIdentifier": "6385", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hori,  Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "6386", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Teraishi,  Toshiya"}], "nameIdentifiers": [{"nameIdentifier": "6387", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hattori,  Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "6388", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  Miho"}], "nameIdentifiers": [{"nameIdentifier": "6389", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo,  Junko"}], "nameIdentifiers": [{"nameIdentifier": "6390", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamoto,  Yumiko"}], "nameIdentifiers": [{"nameIdentifier": "6391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kinoshita,  Yukiko"}], "nameIdentifiers": [{"nameIdentifier": "6392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amano,  Naoji"}], "nameIdentifiers": [{"nameIdentifier": "6393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunugi,  Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "6394", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Association_cognitive_performance_interleukin-6.pdf", "filesize": [{"value": "273.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 273000.0, "url": {"label": "Association_cognitive_performance_interleukin-6.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3693/files/Association_cognitive_performance_interleukin-6.pdf"}, "version_id": "bb0ba2e7-3aeb-472d-b002-2418ed88d22c"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Cognitive function", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Interleukin-6", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genetic polymorphism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Intelligence", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/17722", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2014-07-23"}, "publish_date": "2014-07-23", "publish_status": "0", "recid": "3693", "relation": {}, "relation_version_is_last": true, "title": ["Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults"], "weko_shared_id": null}