Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-04-01 |
タイトル |
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タイトル |
Spinocerebellar ataxia type 6 (SCA6): Clinical pilot trial with gabapentin |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.jns.2008.12.017 |
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関連名称 |
10.1016/j.jns.2008.12.017 |
キーワード |
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主題 |
Spinocerebellar ataxia type 6 (SCA6), Gabapentin, The International Cooperative Ataxia Rating Scales (ICARS), Voltage-dependent calcium channel (VDCC), gamma-aminobutyric acid (GABA), Postural sway study |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Nakamura, Katsuya
Yoshida, Kunihiro
Miyazaki, Daigo
Morita, Hiroshi
Ikeda, Shu-ichi
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信州大学研究者総覧へのリンク |
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氏名 |
Yoshida, Kunihiro |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yhfNHFkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Morita, Hiroshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyNHhkh.html |
出版者 |
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出版者 |
ELSEVIER SCIENCE BV |
引用 |
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内容記述 |
JOURNAL OF THE NEUROLOGICAL SCIENCES. 278(1-2):107-111 (2009) |
書誌情報 |
JOURNAL OF THE NEUROLOGICAL SCIENCES
巻 278,
号 1-2,
p. 107-111,
発行日 2009-03-15
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抄録 |
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内容記述 |
The clinical effect of the GABAergic drug gabapentin was evaluated in 11 patients with spinocerebellar ataxia type 6 (SCA6). The total period of gabapentin treatment was 4 weeks, and outcome measures were determined with the International Cooperative Ataxia Rating Scales (ICARS) and postural sway studies. At week 4, 5 patients showed a decrease of the ICARS values by more than 10% compared with the pretreatment baseline. Eight patients showed a more than 10% decrease of the sway area (SA) and/or sway path length (SPL) values in postural sway Studies. The ICARS values and SA/SPL values were not necessarily consistent in each patient, but 3 patients showed a more than 10% decrease in the ICRAS, SA, and SPL values at week 4 when compared to the pre-treatment baseline. As a whole, the efficacy of gabapentin was not statistically confirmed in the 4-week trial because of the variation in efficacy in each patient, but the data are indicative that some SCA6 patients could benefit from gabapentin treatment. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0022-510X |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00703265 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/19157422 |
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関連名称 |
19157422 |
権利 |
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権利情報 |
Copyright© 2008 Elsevier B.V. |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000263692300021 |