| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-03-06 |
| タイトル |
|
|
タイトル |
Comparison of acid-induced inflammatory responses in the rat lung during high frequency oscillatory and conventional mechanical ventilation |
| 言語 |
|
|
言語 |
eng |
| DOI |
|
|
|
関連識別子 |
https://doi.org/10.1007/s00011-010-0204-6 |
|
|
関連名称 |
10.1007/s00011-010-0204-6 |
| キーワード |
|
|
主題 |
Mechanical ventilation, Lung injury, Surfactant, ARDS, TNF-alpha, Ventilation-induced lung injury |
| 資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
| 著者 |
Jian, Ming-Yuan
Koizumi, Tomonobu
Yokoyama, Toshiki
Tsushima, Kenji
Kubo, Keishi
|
| 信州大学研究者総覧へのリンク |
|
|
氏名 |
Koizumi, Tomonobu |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.WakmHhkh.html |
| 出版者 |
|
|
出版者 |
SPRINGER BASEL AG |
| 引用 |
|
|
内容記述 |
INFLAMMATION RESEARCH. 59(11):931-937 (2010) |
| 書誌情報 |
INFLAMMATION RESEARCH
巻 59,
号 11,
p. 931-937,
発行日 2010-11
|
| 抄録 |
|
|
内容記述 |
The present study was performed to compare the effects of high frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation (CMV) on pulmonary inflammatory responses in a rat acid-induced lung injury model. Anesthetized rats were instilled intratracheally with HCl (0.1 N, 2 mL/kg) and then randomly divided into three mechanical ventilation settings: HFOV (an oscillatory frequency of 15 Hz, mean airway pressure (MAP) of 9 cmH(2)O), CMV at tidal volume of 12 and 6 mL/kg for 5 h. After HCl instillation, HFOV significantly attenuated the increases in neutrophil infiltration and TNF-alpha concentration in bronchoalveolar lavage fluid compared with the CMV groups. During HFOV, there was an inhibition of an increase in TNF-alpha mRNA expression and a decrease in SP-A mRNA expression induced by acid instillation. This animal study demonstrates that HFOV is a suitable form of mechanical ventilation to prevent inflammatory responses in acid-induced lung injury. |
| 資源タイプ（コンテンツの種類） |
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1023-3830 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11030494 |
| PubMed |
|
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20425135 |
|
|
関連名称 |
20425135 |
| 権利 |
|
|
権利情報 |
The final publication is available at www.springerlink.com |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282218900005 |
Comparison_acid-induced_inflammatory_responses_rat_lung.pdf (160.4 kB)
