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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

An Integrin alpha 4 beta 7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue

http://hdl.handle.net/10091/16235
http://hdl.handle.net/10091/16235
3441b4da-0840-4187-a75f-aec58480af78
名前 / ファイル ライセンス アクション
An_Integrin_alpha_4_beta_7_IgG_Heterodimeric_Chimera.pdf An_Integrin_alpha_4_beta_7_IgG_Heterodimeric_Chimera.pdf (932.5 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-02-04
タイトル
タイトル An Integrin alpha 4 beta 7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1369/0022155411404416
関連名称 10.1369/0022155411404416
キーワード
主題 alpha 4 beta 7 integrin, functional probe, gut-associated lymphoid tissue (GALT), high endothelial venule (HEV), lymphocyte homing, mucosal addressin cell adhesion molecule 1 (MAdCAM-1)
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hoshino, Hitomi

× Hoshino, Hitomi

en Hoshino, Hitomi

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Kobayashi, Motohiro

× Kobayashi, Motohiro

en Kobayashi, Motohiro

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Mitoma, Junya

× Mitoma, Junya

en Mitoma, Junya

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Sato, Yoshiko

× Sato, Yoshiko

en Sato, Yoshiko

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Fukuda, Minoru

× Fukuda, Minoru

en Fukuda, Minoru

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Nakayama, Jun

× Nakayama, Jun

en Nakayama, Jun

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信州大学研究者総覧へのリンク
氏名 Nakayama, Jun
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html
出版者
出版者 SAGE PUBLICATIONS LTD
引用
内容記述 JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 59(6):572-583 (2011)
書誌情報 JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

巻 59, 号 6, p. 572-583, 発行日 2011-06
抄録
内容記述 Lymphocyte homing is regulated by a multistep process mediated by sequential adhesive interactions between circulating lymphocytes and high endothelial venules (HEVs). In gut-associated lymphoid tissue (GALT), the initial interactive step, "tethering and rolling," is partly mediated by integrin alpha 4 beta 7 expressed on GALT-homing lymphocytes and its ligand MAdCAM-1, which is exclusively expressed on HEVs in GALT. To probe functional MAdCAM-1 in tissue sections, we developed a soluble integrin alpha 4 beta 7 heterodimeric IgG chimera by joining the extracellular region of mouse integrin alpha 4 and beta 7 subunits to a human IgG Fc domain. Western blot analysis revealed that co-transfection of HEK 293T cells with expression vectors encoding integrin alpha 4.IgG and beta 7.IgG results in the formation of alpha 4 beta 7.IgG heterodimeric chimeras. This complex preferentially binds to CHO cells expressing MAdCAM-1 and, to a lesser extent, to cells expressing VCAM-1, but not to cells expressing ICAM-1. Moreover, alpha 4 beta 7.IgG specifically binds to HEVs in GALT in situ in a divalent cation-dependent fashion and inhibits lymphocyte binding to HEVs in GALT. These findings indicate that alpha 4 beta 7.IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration. (J Histochem Cytochem 59:572-583, 2011)
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ PISSN
収録物識別子 0022-1554
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA0069926X
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21430257
関連名称 21430257
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000293703900001
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Cite as

Hoshino, Hitomi, Kobayashi, Motohiro, Mitoma, Junya, Sato, Yoshiko, Fukuda, Minoru, Nakayama, Jun, 2011, An Integrin alpha 4 beta 7.IgG Heterodimeric Chimera Binds to MAdCAM-1 on High Endothelial Venules in Gut-Associated Lymphoid Tissue: SAGE PUBLICATIONS LTD, 572–583 p.

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