Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-02-04 |
タイトル |
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タイトル |
Exercise Effects on Methylation of ASC Gene |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1055/s-0029-1246140 |
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関連名称 |
10.1055/s-0029-1246140 |
キーワード |
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主題 |
interval walking, pyrosequencing, age |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Nakajima, K
Takeoka, M
Mori, M
Hashimoto, S
Sakurai, A
Nose, H
Higuchi, K
Itano, N
Shiohara, M
Oh, T
Taniguchi, S
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信州大学研究者総覧へのリンク |
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氏名 |
Nose, H |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyVuUkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Higuchi, K |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Taniguchi, S |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.HCyUHCDV.html |
出版者 |
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出版者 |
GEORG THIEME VERLAG KG |
引用 |
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内容記述 |
INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 31(9):671-675 (2010) |
書誌情報 |
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
巻 31,
号 9,
p. 671-675,
発行日 2010-09
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抄録 |
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内容記述 |
Chronic moderate exercise has been reported to reduce pro-inflammatory cytokines. To analyze the molecular mechanisms by which training exerts these effects, the epigenetic influences of age and exercise on the ASC gene, which is responsible for IL-1 beta and IL-18 secretion, were investigated by ASC gene methylation. Further, the relationship between carcinogenesis and exercise, and methylation of the p15 tumor suppressive gene was also analyzed. High-intensity interval walking exercise, consisting of 3 min low-intensity walking at 40% of peak aerobic capacity followed by a 3 min high-intensity walking period above 70% of peak aerobic capacity, was continued for 6 months. Peripheral blood DNA extracts from young control (n = 34), older control (n = 153), and older exercise (n = 230) groups were then analyzed by pyrosequencing for DNA methylation. Methylation of ASC decreased significantly with age (young control vs. older control, p < 0.01), which is indicative of an age-dependent increase in ASC expression. Compared to the older control group, the degree of ASC methylation was higher in the older exercise group (older control vs. older exercise: p < 0.01), and presumably lower ASC expression. Neither exercise nor age affected the methylation of the p15. In summary, chronic moderate exercise appears to attenuate the age-dependent decrease in ASC methylation, implying suppression of excess pro-inflammatory cytokines through reduction of ASC expression. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0172-4622 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00234368 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20200803 |
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関連名称 |
20200803 |
権利 |
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権利情報 |
Copyright© 2010 Georg Thieme Verlag KG Stuttgart |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282656000011 |