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To analyze the molecular mechanisms by which training exerts these effects, the epigenetic influences of age and exercise on the ASC gene, which is responsible for IL-1 beta and IL-18 secretion, were investigated by ASC gene methylation. Further, the relationship between carcinogenesis and exercise, and methylation of the p15 tumor suppressive gene was also analyzed. High-intensity interval walking exercise, consisting of 3 min low-intensity walking at 40% of peak aerobic capacity followed by a 3 min high-intensity walking period above 70% of peak aerobic capacity, was continued for 6 months. Peripheral blood DNA extracts from young control (n = 34), older control (n = 153), and older exercise (n = 230) groups were then analyzed by pyrosequencing for DNA methylation. Methylation of ASC decreased significantly with age (young control vs. older control, p \u003c 0.01), which is indicative of an age-dependent increase in ASC expression. 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To analyze the molecular mechanisms by which training exerts these effects, the epigenetic influences of age and exercise on the ASC gene, which is responsible for IL-1 beta and IL-18 secretion, were investigated by ASC gene methylation. Further, the relationship between carcinogenesis and exercise, and methylation of the p15 tumor suppressive gene was also analyzed. High-intensity interval walking exercise, consisting of 3 min low-intensity walking at 40% of peak aerobic capacity followed by a 3 min high-intensity walking period above 70% of peak aerobic capacity, was continued for 6 months. Peripheral blood DNA extracts from young control (n = 34), older control (n = 153), and older exercise (n = 230) groups were then analyzed by pyrosequencing for DNA methylation. Methylation of ASC decreased significantly with age (young control vs. older control, p \u003c 0.01), which is indicative of an age-dependent increase in ASC expression. Compared to the older control group, the degree of ASC methylation was higher in the older exercise group (older control vs. older exercise: p \u003c 0.01), and presumably lower ASC expression. Neither exercise nor age affected the methylation of the p15. 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Exercise Effects on Methylation of ASC Gene
http://hdl.handle.net/10091/16233
http://hdl.handle.net/10091/162338a34b3c1-f0f1-48ae-a311-b8a5bb52f2fa
名前 / ファイル | ライセンス | アクション |
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Exercise_effects_methylation_ASC_gene.pdf (375.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-02-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Exercise Effects on Methylation of ASC Gene | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1055/s-0029-1246140 | |||||
関連名称 | 10.1055/s-0029-1246140 | |||||
キーワード | ||||||
主題 | interval walking, pyrosequencing, age | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Nakajima, K
× Nakajima, K× Takeoka, M× Mori, M× Hashimoto, S× Sakurai, A× Nose, H× Higuchi, K× Itano, N× Shiohara, M× Oh, T× Taniguchi, S |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Nose, H | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HUyVuUkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Higuchi, K | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCfUPmAh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Taniguchi, S | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCyUHCDV.html | |||||
出版者 | ||||||
出版者 | GEORG THIEME VERLAG KG | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 31(9):671-675 (2010) | |||||
書誌情報 |
INTERNATIONAL JOURNAL OF SPORTS MEDICINE 巻 31, 号 9, p. 671-675, 発行日 2010-09 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chronic moderate exercise has been reported to reduce pro-inflammatory cytokines. To analyze the molecular mechanisms by which training exerts these effects, the epigenetic influences of age and exercise on the ASC gene, which is responsible for IL-1 beta and IL-18 secretion, were investigated by ASC gene methylation. Further, the relationship between carcinogenesis and exercise, and methylation of the p15 tumor suppressive gene was also analyzed. High-intensity interval walking exercise, consisting of 3 min low-intensity walking at 40% of peak aerobic capacity followed by a 3 min high-intensity walking period above 70% of peak aerobic capacity, was continued for 6 months. Peripheral blood DNA extracts from young control (n = 34), older control (n = 153), and older exercise (n = 230) groups were then analyzed by pyrosequencing for DNA methylation. Methylation of ASC decreased significantly with age (young control vs. older control, p < 0.01), which is indicative of an age-dependent increase in ASC expression. Compared to the older control group, the degree of ASC methylation was higher in the older exercise group (older control vs. older exercise: p < 0.01), and presumably lower ASC expression. Neither exercise nor age affected the methylation of the p15. In summary, chronic moderate exercise appears to attenuate the age-dependent decrease in ASC methylation, implying suppression of excess pro-inflammatory cytokines through reduction of ASC expression. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0172-4622 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00234368 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20200803 | |||||
関連名称 | 20200803 | |||||
権利 | ||||||
権利情報 | Copyright© 2010 Georg Thieme Verlag KG Stuttgart | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000282656000011 |