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Skeletal muscle is a major mass peripheral tissue that accounts for 40% of total body weight and 50% of energy consumption. We focused on the differentiation pathway of myoblasts after exposure to a vapor-grown carbon fiber, HTT2800, which is one of the most highly purified carbon nanotubes. This treatment leads in parallel to the expression of a typical adipose differentiation program. We found that HTT2800 stimulated intracellular lipid accumulation in C2C12 cells. We have also shown by quantified PCR analysis that the expression of adipose-related genes was markedly upregulated during HTT2800 exposure. Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells. (C) 2011 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsukahara,  Tamotsu"}], "nameIdentifiers": [{"nameIdentifier": "7544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haniu,  Hisao"}], "nameIdentifiers": [{"nameIdentifier": "7545", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Nanoparticle-mediated_intracellular_lipid_accumulation.pdf", "filesize": [{"value": "669.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 669800.0, "url": {"label": "Nanoparticle-mediated_intracellular_lipid_accumulation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3855/files/Nanoparticle-mediated_intracellular_lipid_accumulation.pdf"}, "version_id": "d1f720bd-0235-408b-a6e8-aad59a6b43cb"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Myoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Adipoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Multiwall carbon nanotube", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lipid accumulation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/13166", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2011-05-23"}, "publish_date": "2011-05-23", "publish_status": "0", "recid": "3855", "relation": {}, "relation_version_is_last": true, "title": ["Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation"], "weko_shared_id": null}