{"_buckets": {"deposit": "e1aaee00-7a74-431b-8eb2-7536dc3c8e7c"}, "_deposit": {"id": "3855", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3855"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003855", "sets": ["462"]}, "author_link": ["7544", "7545"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "563", "bibliographicPageStart": "558", "bibliographicVolumeNumber": "406", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In this report, we sought to elucidate whether multiwall carbon nanotubes are involved in the modulation of the proliferation and differentiation of the skeletal muscle cell line C2C12. 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Skeletal muscle is a major mass peripheral tissue that accounts for 40% of total body weight and 50% of energy consumption. We focused on the differentiation pathway of myoblasts after exposure to a vapor-grown carbon fiber, HTT2800, which is one of the most highly purified carbon nanotubes. This treatment leads in parallel to the expression of a typical adipose differentiation program. We found that HTT2800 stimulated intracellular lipid accumulation in C2C12 cells. We have also shown by quantified PCR analysis that the expression of adipose-related genes was markedly upregulated during HTT2800 exposure. Taken together, these results suggest that HTT2800 specifically converts the differentiation pathway of C2C12 myoblasts to that of adipoblast-like cells. (C) 2011 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsukahara,  Tamotsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7544", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Haniu,  Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7545", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Nanoparticle-mediated_intracellular_lipid_accumulation.pdf", "filesize": [{"value": "669.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 669800.0, "url": {"label": "Nanoparticle-mediated_intracellular_lipid_accumulation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3855/files/Nanoparticle-mediated_intracellular_lipid_accumulation.pdf"}, "version_id": "d1f720bd-0235-408b-a6e8-aad59a6b43cb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Myoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Adipoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Multiwall carbon nanotube", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lipid accumulation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/13166", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2011-05-23"}, "publish_date": "2011-05-23", "publish_status": "0", "recid": "3855", "relation": {}, "relation_version_is_last": true, "title": ["Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation"], "weko_shared_id": -1}