Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2011-01-18 |
タイトル |
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タイトル |
Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1111/j.1399-3046.2008.01065.x |
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関連名称 |
10.1111/j.1399-3046.2008.01065.x |
キーワード |
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主題 |
intermediate dose of TBI-containing regimen, fludarabine, HLA-mismatched donors, allogeneic hematopoietic stem cell transplantation, pediatric hematological malignancies |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Yanagisawa, Ryu
Nakazawa, Yozo
Sakashita, Kazuo
Tanaka, Miyuki
Shikama, Naoto
Kamijo, Takehiko
Shiohara, Masaaki
Koike, Kenichi
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信州大学研究者総覧へのリンク |
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氏名 |
Nakazawa, Yozo |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html |
出版者 |
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出版者 |
WILEY-BLACKWELL PUBLISHING, INC |
引用 |
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内容記述 |
PEDIATRIC TRANSPLANTATION. 13(6):737-745 (2009) |
書誌情報 |
en : PEDIATRIC TRANSPLANTATION
巻 13,
号 6,
p. 737-745,
発行日 2009-09
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内容記述 |
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内容記述 |
The definitive version is available at www.blackwell-synergy.com |
抄録 |
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内容記述 |
We here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies. Among 22 children who received related or unrelated HSCT, nine were transplanted with refractory disease and/or from HLA two or more loci-mismatched family donors. None of the patients developed graft failure. The Seattle grading system revealed that 18 patients had no RRT, and the remaining patients had grade I gastrointestinal toxicity alone. The estimated overall survival and leukemia-free survival at two yr were 57.1% and 48.0%, respectively, in 10 patients with acute lymphoblastic leukemia; 91.7% and 71.3%, respectively, in 12 patients with myeloid leukemia. The incidence of TRM was 4.8% at two yr. The rates of RRT above grade II and TRM in an 8-Gy TBI-containing regimen were significantly lower than the data of historical control patients who underwent 12-Gy TBI and cyclophosphamide with or without etoposide. The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1397-3142 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11202523 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/19207225 |
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関連名称 |
19207225 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000268793800013 |