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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies

http://hdl.handle.net/10091/11099
ca3f3334-50df-4bd0-b450-4d3af58a44e4
名前 / ファイル ライセンス アクション
Low_toxicity_conditioning_8-Gy_total_body_irradiation.pdf Low_toxicity_conditioning_8-Gy_total_body_irradiation.pdf (435.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2011-01-18
タイトル
言語 en
タイトル Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies
言語
言語 eng
キーワード
主題Scheme Other
主題 intermediate dose of TBI-containing regimen
キーワード
主題Scheme Other
主題 fludarabine
キーワード
主題Scheme Other
主題 HLA-mismatched donors
キーワード
主題Scheme Other
主題 allogeneic hematopoietic stem cell transplantation
キーワード
主題Scheme Other
主題 pediatric hematological malignancies
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yanagisawa, Ryu

× Yanagisawa, Ryu

WEKO 7655

en Yanagisawa, Ryu

Search repository
Nakazawa, Yozo

× Nakazawa, Yozo

WEKO 7656

en Nakazawa, Yozo

Search repository
Sakashita, Kazuo

× Sakashita, Kazuo

WEKO 7657

en Sakashita, Kazuo

Search repository
Tanaka, Miyuki

× Tanaka, Miyuki

WEKO 7658

en Tanaka, Miyuki

Search repository
Shikama, Naoto

× Shikama, Naoto

WEKO 7659

en Shikama, Naoto

Search repository
Kamijo, Takehiko

× Kamijo, Takehiko

WEKO 7660

en Kamijo, Takehiko

Search repository
Shiohara, Masaaki

× Shiohara, Masaaki

WEKO 7661

en Shiohara, Masaaki

Search repository
Koike, Kenichi

× Koike, Kenichi

WEKO 7662

en Koike, Kenichi

Search repository
信州大学研究者総覧へのリンク
氏名 Nakazawa, Yozo
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yCSFuNkh.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述タイプ Other
内容記述 PEDIATRIC TRANSPLANTATION. 13(6):737-745 (2009)
書誌情報 en : PEDIATRIC TRANSPLANTATION

巻 13, 号 6, p. 737-745, 発行日 2009-09
内容記述
内容記述タイプ Other
内容記述 The definitive version is available at www.blackwell-synergy.com
抄録
内容記述タイプ Abstract
内容記述 We here report the efficacy and toxicity of a conditioning regimen with fractionated 8-Gy TBI, fludarabine, and cyclophosphamide in allogeneic HSCT for pediatric hematological malignancies. Among 22 children who received related or unrelated HSCT, nine were transplanted with refractory disease and/or from HLA two or more loci-mismatched family donors. None of the patients developed graft failure. The Seattle grading system revealed that 18 patients had no RRT, and the remaining patients had grade I gastrointestinal toxicity alone. The estimated overall survival and leukemia-free survival at two yr were 57.1% and 48.0%, respectively, in 10 patients with acute lymphoblastic leukemia; 91.7% and 71.3%, respectively, in 12 patients with myeloid leukemia. The incidence of TRM was 4.8% at two yr. The rates of RRT above grade II and TRM in an 8-Gy TBI-containing regimen were significantly lower than the data of historical control patients who underwent 12-Gy TBI and cyclophosphamide with or without etoposide. The intermediate-dose TBI-based conditioning regimen may confer successful engraftment combined with minimized RRT, although its efficacy should be further evaluated.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1397-3142
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11202523
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/19207225
関連名称
関連名称 19207225
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1399-3046.2008.01065.x
関連名称
関連名称 10.1111/j.1399-3046.2008.01065.x
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000268793800013
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