{"_buckets": {"deposit": "3066ba66-e0c1-4d96-8237-00981a2bed25"}, "_deposit": {"id": "3869", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "3869"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00003869", "sets": ["461:462"]}, "author_link": ["7663", "7664", "7665", "7666", "7667", "7668", "7669"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-10-16", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "300", "bibliographicPageStart": "297", "bibliographicVolumeNumber": "388", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The present study was performed to examine a role of oxidative stress in oleic acid-induced lung injury model. Fifteen anesthetized sheep were ventilated and instrumented with a lung lymph fistula and vascular catheters for blood gas analysis and measurement of isoprostanes (8-epi prostaglandin F2 alpha). Following stable baseline measurements, oleic acid (0.08 ml/kg) was administered and observed 4 h. Isoprostane was measured by gas chromatography mass spectrometry with the isotope dilution method. Isoprostane levels in plasma and lung lymph were significantly increased 2 h after oleic acid administration and then decreased at 4 h. The percent increases in isoprostane levels in plasma and lung lymph at 2 h were significantly correlated with deteriorated oxygenation at the same time point, respectively. 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Fifteen anesthetized sheep were ventilated and instrumented with a lung lymph fistula and vascular catheters for blood gas analysis and measurement of isoprostanes (8-epi prostaglandin F2 alpha). Following stable baseline measurements, oleic acid (0.08 ml/kg) was administered and observed 4 h. Isoprostane was measured by gas chromatography mass spectrometry with the isotope dilution method. Isoprostane levels in plasma and lung lymph were significantly increased 2 h after oleic acid administration and then decreased at 4 h. The percent increases in isoprostane levels in plasma and lung lymph at 2 h were significantly correlated with deteriorated oxygenation at the same time point, respectively. These findings suggest that oxidative stress is involved in the pathogenesis of the pulmonary fat embolism-induced acute lung injury model in sheep and that the increase relates with the deteriorated oxygenation. (C) 2009 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ono,  Koichi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7663", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koizumi,  Tomonobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7664", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsushima,  Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7665", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshikawa,  Sumiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7666", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoyama,  Toshiki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7667", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakagawa,  Rikimaru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7668", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Obata,  Toru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "7669", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Increased_isoprostane_levels_oleic_acid.pdf", "filesize": [{"value": "263.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 263600.0, "url": {"label": "Increased_isoprostane_levels_oleic_acid.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3869/files/Increased_isoprostane_levels_oleic_acid.pdf"}, "version_id": "06e2cd99-26e7-4711-91c4-1c9459050527"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Oleic acid-induced lung injury", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lung lymph flow", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Increased permeability edema", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sheep", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidant stress", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Increased isoprostane levels in oleic acid-induced lung injury", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Increased isoprostane levels in oleic acid-induced lung injury", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/11096", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2011-01-17"}, "publish_date": "2011-01-17", "publish_status": "0", "recid": "3869", "relation": {}, "relation_version_is_last": true, "title": ["Increased isoprostane levels in oleic acid-induced lung injury"], "weko_shared_id": -1}