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To verify occurrence of PPAR\u03b1-independent peroxisome proliferation, fenofibrate treatment was used, which was expected to significantly enhance PPAR\u03b1 dependence in the assay system. Surprisingly, a novel type of PPAR\u03b1-independent peroxisome proliferation and enlargement was uncovered in PPAR\u03b1-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11\u03b1, might be associated with the PPAR\u03b1-independent peroxisome proliferation at least in part.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\uff1amime\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346(4): 1307-1311(2006)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Kamijo, Y", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000239016600027"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "ACADEMIC PRESS INC ELSEVIER SCIENCE"}]}, "item_6_relation_46": {"attribute_name": "\u4ed6\u306e\u8cc7\u6e90\u3068\u306e\u95a2\u4fc2\uff1aURI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description", "subitem_relation_type_select": "URI"}}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "16806075"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=16806075", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.bbrc.2006.06.042"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1016/j.bbrc.2006.06.042", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564395", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_69": {"attribute_name": "wosonly authkey", "attribute_value_mlt": [{"subitem_text_value": "peroxisome proliferator-activated receptor alpha; peroxisome proliferation; morphometry; dynamin-like protein 1"}]}, "item_6_text_70": {"attribute_name": "wosonly keywords", "attribute_value_mlt": [{"subitem_text_value": "PPAR-ALPHA; NULL MICE; RAT-LIVER; EXPRESSION; ACID; GENE; RETICULUM; WY-14,643; AGONIST; ENZYMES"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "Hepatic peroxisome proliferation, increases in the numerical and volume density of peroxisomes, is believed to be closely related to peroxisome proliferator-activated receptor alpha (PPAR alpha) activation; however, it remains unknown whether peroxisome proliferation depends absolutely on this activation. To verify occurrence of PPAR alpha-independent peroxisome proliferation, fenofibrate treatment was used. which was expected to significantly enhance PPAR alpha dependence in the assay system. Surprisingly, a novel type of PPAR alpha-independent peroxisome proliferation and enlargement was uncovered in PPAR alpha-null mice. The increased expression of dynamin-like protein 1, but not peroxisome biogenesis factor 11 alpha, might be associated with the PPAR alpha-independent peroxisome proliferation at least in part. (c) 2006 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhang,  XG"}], "nameIdentifiers": [{"nameIdentifier": "8134", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka,  N"}], "nameIdentifiers": [{"nameIdentifier": "8135", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima,  T"}], "nameIdentifiers": [{"nameIdentifier": "8136", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamijo,  Y"}], "nameIdentifiers": [{"nameIdentifier": "8137", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Gonzalez,  FJ"}], "nameIdentifiers": [{"nameIdentifier": "8138", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoyama,  T"}], "nameIdentifiers": [{"nameIdentifier": "8139", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PPARa-independentPP_ZhangX_etal.pdf", "filesize": [{"value": "184.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 184900.0, "url": {"label": "PPARa-independentPP_ZhangX_etal.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/3937/files/PPARa-independentPP_ZhangX_etal.pdf"}, "version_id": "0eacf014-4891-470c-8122-7f1ac6d398d2"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "peroxisome proliferator-activated receptor \u03b1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "peroxisome proliferation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "morphometry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dynamin-like protein 1", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Peroxisome proliferator-activated receptor \u03b1-independent peroxisome proliferation", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Peroxisome proliferator-activated receptor \u03b1-independent peroxisome proliferation"}]}, "item_type_id": "6", "owner": "1", "path": ["461/462"], "permalink_uri": "http://hdl.handle.net/10091/3105", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2009-06-18"}, "publish_date": "2009-06-18", "publish_status": "0", "recid": "3937", "relation": {}, "relation_version_is_last": true, "title": ["Peroxisome proliferator-activated receptor \u03b1-independent peroxisome proliferation"], "weko_shared_id": 3}