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Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats
http://hdl.handle.net/10091/10139
http://hdl.handle.net/10091/1013908f2d091-eac5-4105-bdae-cbf14464fb1c
| 名前 / ファイル | ライセンス | アクション |
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Shinshu_Med58-3-03.pdf (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2010-06-23 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 関連識別子 | https://doi.org/10.11441/shinshumedj.58.103 | |||||||||||||
| 関連名称 | 10.11441/shinshumedj.58.103 | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | irradiation, human lung fibroblast, chemotaxis, IL-8, MCP-1 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | journal article | |||||||||||||
| 著者 |
NAKAYAMA, Tsuyoshi
× NAKAYAMA, Tsuyoshi
× IMAMURA, Tetsuya
× ISHIZUKA, Osamu
× NISHIZAWA, Osamu
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| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | ISHIZUKA, Osamu | |||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html | |||||||||||||
| 信州大学研究者総覧へのリンク | ||||||||||||||
| 氏名 | NISHIZAWA, Osamu | |||||||||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 信州医学会 | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | 信州医学雑誌. 58(3): 103-114 (2010) | |||||||||||||
| 書誌情報 |
信州医学雑誌 巻 58, 号 3, p. 103-114, 発行日 2010-06-10 |
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| 抄録 | ||||||||||||||
| 内容記述 | Background :To clarify the mechanisms of lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH), we investigated the expression of α1-adrenergic receptor (AR) subtypes and the angiotensin II type 1 receptor (AT1) within the prostate of spontaneously hypertensive rats (SHRs). Methods :Twelve male 25-week-old SHRs and Wistar Kyoto (WKY) rats were randomly separated into two groups (n =6 each). One group was given 20 ml 0.9% sodium chloride solution (saline) orally per kg-body weight daily for one week. The other group received no treatment. After 7 days of saline loading, systolic blood pressure (SBP) and prostate weight were measured. The prostates were immunohistochemically analyzed for α1-AR subtypes and AT1. Results :After 7 days, the SBP and prostate weight of saline-loaded SHRs tended to increase, but was not significantly different compared to the untreated rats.The expression ofα1-AR subtypes and AT1 within the prostates of saline-loaded SHRs was higher than in the untreated ones. In contrast, the expression in the saline-loaded WKY rat prostates did not increase compared to the untreated ones. Conclusion : Increased numbers of α1-AR subtypes and AT1 in saline-loaded SHR prostates might play important roles in the development of LUTS associated with BPH. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0037-3826 | |||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00120815 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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Cite as
NAKAYAMA, Tsuyoshi, IMAMURA, Tetsuya, ISHIZUKA, Osamu, NISHIZAWA, Osamu, 2010, Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats: 信州医学会, 103–114 p.
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