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Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats
http://hdl.handle.net/10091/10139
http://hdl.handle.net/10091/1013908f2d091-eac5-4105-bdae-cbf14464fb1c
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-06-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptor in the Prostate of Spontaneously Hypertensive Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | irradiation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | human lung fibroblast | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chemotaxis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-8 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | MCP-1 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
NAKAYAMA, Tsuyoshi
× NAKAYAMA, Tsuyoshi× IMAMURA, Tetsuya× ISHIZUKA, Osamu× NISHIZAWA, Osamu |
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信州大学研究者総覧へのリンク | ||||||
氏名 | ISHIZUKA, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | NISHIZAWA, Osamu | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html | |||||
出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌. 58(3): 103-114 (2010) | |||||
書誌情報 |
信州医学雑誌 巻 58, 号 3, p. 103-114, 発行日 2010-06-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background :To clarify the mechanisms of lower urinary tract symptoms (LUTS) associated with benign prostate hyperplasia (BPH), we investigated the expression of α1-adrenergic receptor (AR) subtypes and the angiotensin II type 1 receptor (AT1) within the prostate of spontaneously hypertensive rats (SHRs). Methods :Twelve male 25-week-old SHRs and Wistar Kyoto (WKY) rats were randomly separated into two groups (n =6 each). One group was given 20 ml 0.9% sodium chloride solution (saline) orally per kg-body weight daily for one week. The other group received no treatment. After 7 days of saline loading, systolic blood pressure (SBP) and prostate weight were measured. The prostates were immunohistochemically analyzed for α1-AR subtypes and AT1. Results :After 7 days, the SBP and prostate weight of saline-loaded SHRs tended to increase, but was not significantly different compared to the untreated rats.The expression ofα1-AR subtypes and AT1 within the prostates of saline-loaded SHRs was higher than in the untreated ones. In contrast, the expression in the saline-loaded WKY rat prostates did not increase compared to the untreated ones. Conclusion : Increased numbers of α1-AR subtypes and AT1 in saline-loaded SHR prostates might play important roles in the development of LUTS associated with BPH. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11441/shinshumedj.58.103 | |||||
関連名称 | 10.11441/shinshumedj.58.103 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |