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ニホンザル移植心における血管内皮増殖因子の発現
http://hdl.handle.net/10091/9260
5dc9899e-c3d4-4694-8139-648dde78f399
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-24 | |||||
タイトル | ||||||
タイトル | ニホンザル移植心における血管内皮増殖因子の発現 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heart transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic rejection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | coronary arteriosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vascular endothelial growth factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心臓移植 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 慢性拒絶 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 冠動脈硬化 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 血管内皮増殖因子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | Expression of Vascular Endothelial Growth Factor in Cardiac Allografts of Non-Human Primates | |||||
著者 |
渡辺, 智治
× 渡辺, 智治× 鈴木, 淳一× 横関, 整× 天野, 純× 磯部, 光章 |
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出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌 47(5): 393-395(1999) | |||||
書誌情報 |
信州医学雑誌 巻 47, 号 5, p. 393-395, 発行日 1999-10-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Vascular endothelial growth factor (VEGF) plays important roles in regulating angiogenesis. In chronically rejected cardiac allografts, arterial intimal thickening is formed of proliferative smooth muscle cells (SMCs) with enhanced expression of SMemb, a non-muscle myosin heavy chain isoform. However, the detailed mechanisms of the development of these lesions are almost unknown.Heterotopic cardiac transplantation was performed using Japanese monkeys;the grafts were harvested on day 28.Coronary arteries in the transplanted hearts (n=5), recipient native hearts (n=5) and nontransplanted hearts (n=5) were used for pathological analysis. To evaluate VEGF and SMemb expression,we performed immunohistochemistry and the intensity was semiquantitatively scored. VEGF and SMemb reactivity was localized predominately on vascular endothelial cells and SMCs;no immunoreactivity was detected in native hearts.Using serial sections, expression of VEGF and SMemb was seen to be enhanced in the thickened intima,while this expression was diminished in native hearts.The scores of VEGF and SMemb in the vasculature of transplanted hearts were significantly different from those of native hearts (P<0.01).These results indicate that VEGF plays a pivotal role in neointimal formation in chronic rejection, and the expression can be a useful marker for the early diagnosis of chronic rejection in cardiac allografts. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 |