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  1. 050 医学部, 大学院医学系研究科
  2. 0502 紀要・刊行物
  3. 05021 信州医学雑誌
  4. Vol. 47 No. 5

ニホンザル移植心における血管内皮増殖因子の発現

http://hdl.handle.net/10091/9260
5dc9899e-c3d4-4694-8139-648dde78f399
名前 / ファイル ライセンス アクション
Shinshu_Med47-5-05.pdf Shinshu_Med47-5-05.pdf (390.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-03-24
タイトル
タイトル ニホンザル移植心における血管内皮増殖因子の発現
言語
言語 jpn
キーワード
主題Scheme Other
主題 heart transplantation
キーワード
主題Scheme Other
主題 chronic rejection
キーワード
主題Scheme Other
主題 coronary arteriosclerosis
キーワード
主題Scheme Other
主題 vascular endothelial growth factor
キーワード
主題Scheme Other
主題 心臓移植
キーワード
主題Scheme Other
主題 慢性拒絶
キーワード
主題Scheme Other
主題 冠動脈硬化
キーワード
主題Scheme Other
主題 血管内皮増殖因子
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
その他(別言語等)のタイトル
その他のタイトル Expression of Vascular Endothelial Growth Factor in Cardiac Allografts of Non-Human Primates
著者 渡辺, 智治

× 渡辺, 智治

WEKO 10356

渡辺, 智治

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鈴木, 淳一

× 鈴木, 淳一

WEKO 10357

鈴木, 淳一

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横関, 整

× 横関, 整

WEKO 10358

横関, 整

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天野, 純

× 天野, 純

WEKO 10359

天野, 純

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磯部, 光章

× 磯部, 光章

WEKO 10360

磯部, 光章

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出版者
出版者 信州医学会
引用
内容記述タイプ Other
内容記述 信州医学雑誌 47(5): 393-395(1999)
書誌情報 信州医学雑誌

巻 47, 号 5, p. 393-395, 発行日 1999-10-10
抄録
内容記述タイプ Abstract
内容記述 Vascular endothelial growth factor (VEGF) plays important roles in regulating angiogenesis. In chronically rejected cardiac allografts, arterial intimal thickening is formed of proliferative smooth muscle cells (SMCs) with enhanced expression of SMemb, a non-muscle myosin heavy chain isoform. However, the detailed mechanisms of the development of these lesions are almost unknown.Heterotopic cardiac transplantation was performed using Japanese monkeys;the grafts were harvested on day 28.Coronary arteries in the transplanted hearts (n=5), recipient native hearts (n=5) and nontransplanted hearts (n=5) were used for pathological analysis. To evaluate VEGF and SMemb expression,we performed immunohistochemistry and the intensity was semiquantitatively scored. VEGF and SMemb reactivity was localized predominately on vascular endothelial cells and SMCs;no immunoreactivity was detected in native hearts.Using serial sections, expression of VEGF and SMemb was seen to be enhanced in the thickened intima,while this expression was diminished in native hearts.The scores of VEGF and SMemb in the vasculature of transplanted hearts were significantly different from those of native hearts (P<0.01).These results indicate that VEGF plays a pivotal role in neointimal formation in chronic rejection, and the expression can be a useful marker for the early diagnosis of chronic rejection in cardiac allografts.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0037-3826
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00120815
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