Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2010-03-24 |
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タイトル |
マウス移植心冠動脈における単球遊走因子の発現 |
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タイトル |
Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts |
言語 |
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言語 |
jpn |
キーワード |
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主題 |
heart transplantation, chronic rejection, coronary neointimal formation, monocyte chemoattractant protein 心臓移植, 慢性拒絶, 冠動脈肥厚内膜形成, 単球遊走因子 |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
町田, 水穂
鈴木, 淳一
高橋, 済
天野, 純
磯部, 光章
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出版者 |
信州医学会 |
引用 |
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内容記述 |
信州医学雑誌 47(5): 401-404(1999) |
書誌情報 |
信州医学雑誌
巻 47,
号 5,
p. 401-404,
発行日 1999-10-10
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抄録 |
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内容記述 |
Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n=5) and 60 (n=5). For the control study,isografts were used (n=5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. MCP-1 may play pivotal roles in neointimal formation in the early phase of chronic rejection in cardiac allografts. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0037-3826 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AN00120815 |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |