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マウス移植心冠動脈における単球遊走因子の発現
http://hdl.handle.net/10091/9259
94ae7d58-3834-4b40-aa4f-3ab771868864
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-03-24 | |||||
タイトル | ||||||
タイトル | マウス移植心冠動脈における単球遊走因子の発現 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | heart transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chronic rejection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | coronary neointimal formation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monocyte chemoattractant protein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 心臓移植 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 慢性拒絶 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 冠動脈肥厚内膜形成 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 単球遊走因子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts | |||||
著者 |
町田, 水穂
× 町田, 水穂× 鈴木, 淳一× 高橋, 済× 天野, 純× 磯部, 光章 |
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出版者 | ||||||
出版者 | 信州医学会 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州医学雑誌 47(5): 401-404(1999) | |||||
書誌情報 |
信州医学雑誌 巻 47, 号 5, p. 401-404, 発行日 1999-10-10 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n=5) and 60 (n=5). For the control study,isografts were used (n=5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. MCP-1 may play pivotal roles in neointimal formation in the early phase of chronic rejection in cardiac allografts. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0037-3826 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00120815 |