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  1. 050 医学部, 大学院医学系研究科
  2. 0502 紀要・刊行物
  3. 05021 信州医学雑誌
  4. Vol. 47 No. 5

マウス移植心冠動脈における単球遊走因子の発現

http://hdl.handle.net/10091/9259
http://hdl.handle.net/10091/9259
94ae7d58-3834-4b40-aa4f-3ab771868864
名前 / ファイル ライセンス アクション
Shinshu_Med47-5-07.pdf Shinshu_Med47-5-07.pdf (339.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-03-24
タイトル
タイトル マウス移植心冠動脈における単球遊走因子の発現
言語
言語 jpn
キーワード
主題Scheme Other
主題 heart transplantation
キーワード
主題Scheme Other
主題 chronic rejection
キーワード
主題Scheme Other
主題 coronary neointimal formation
キーワード
主題Scheme Other
主題 monocyte chemoattractant protein
キーワード
主題Scheme Other
主題 心臓移植
キーワード
主題Scheme Other
主題 慢性拒絶
キーワード
主題Scheme Other
主題 冠動脈肥厚内膜形成
キーワード
主題Scheme Other
主題 単球遊走因子
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
その他(別言語等)のタイトル
その他のタイトル Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts
著者 町田, 水穂

× 町田, 水穂

WEKO 10365

町田, 水穂

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鈴木, 淳一

× 鈴木, 淳一

WEKO 10366

鈴木, 淳一

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高橋, 済

× 高橋, 済

WEKO 10367

高橋, 済

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天野, 純

× 天野, 純

WEKO 10368

天野, 純

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磯部, 光章

× 磯部, 光章

WEKO 10369

磯部, 光章

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出版者
出版者 信州医学会
引用
内容記述タイプ Other
内容記述 信州医学雑誌 47(5): 401-404(1999)
書誌情報 信州医学雑誌

巻 47, 号 5, p. 401-404, 発行日 1999-10-10
抄録
内容記述タイプ Abstract
内容記述 Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n=5) and 60 (n=5). For the control study,isografts were used (n=5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. MCP-1 may play pivotal roles in neointimal formation in the early phase of chronic rejection in cardiac allografts.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0037-3826
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00120815
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