{"_buckets": {"deposit": "e7375894-c9ad-45c4-b893-e4cba1a378e4"}, "_deposit": {"id": "4376", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4376"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004376", "sets": ["558"]}, "item_6_alternative_title_1": {"attribute_name": "その他（別言語等）のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-10-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "404", "bibliographicPageStart": "401", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "信州医学雑誌"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n＝5) and 60 (n＝5). For the control study,isografts were used (n＝5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. MCP-1 may play pivotal roles in neointimal formation in the early phase of chronic rejection in cardiac allografts.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "信州医学雑誌 47(5): 401-404(1999)", "subitem_description_type": "Other"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州医学会"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00120815", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_66": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "07"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "町田,  水穂"}], "nameIdentifiers": [{"nameIdentifier": "10365", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木,  淳一"}], "nameIdentifiers": [{"nameIdentifier": "10366", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高橋,  済"}], "nameIdentifiers": [{"nameIdentifier": "10367", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "天野,  純"}], "nameIdentifiers": [{"nameIdentifier": "10368", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "磯部,  光章"}], "nameIdentifiers": [{"nameIdentifier": "10369", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Shinshu_Med47-5-07.pdf", "filesize": [{"value": "339.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 339300.0, "url": {"label": "Shinshu_Med47-5-07.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4376/files/Shinshu_Med47-5-07.pdf"}, "version_id": "f5b9a561-fabf-4c49-82c9-0fb505bec302"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "heart transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chronic rejection", "subitem_subject_scheme": "Other"}, {"subitem_subject": "coronary neointimal formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "monocyte chemoattractant protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心臓移植", "subitem_subject_scheme": "Other"}, {"subitem_subject": "慢性拒絶", "subitem_subject_scheme": "Other"}, {"subitem_subject": "冠動脈肥厚内膜形成", "subitem_subject_scheme": "Other"}, {"subitem_subject": "単球遊走因子", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "マウス移植心冠動脈における単球遊走因子の発現", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "マウス移植心冠動脈における単球遊走因子の発現"}]}, "item_type_id": "6", "owner": "1", "path": ["558"], "permalink_uri": "http://hdl.handle.net/10091/9259", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-03-24"}, "publish_date": "2010-03-24", "publish_status": "0", "recid": "4376", "relation": {}, "relation_version_is_last": true, "title": ["マウス移植心冠動脈における単球遊走因子の発現"], "weko_shared_id": 3}