{"_buckets": {"deposit": "e7375894-c9ad-45c4-b893-e4cba1a378e4"}, "_deposit": {"id": "4376", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4376"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004376"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\uff08\u5225\u8a00\u8a9e\u7b49\uff09\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Expression of Monocyte Chemoattractant Protein-1 in Coronary Arteries of Murine Cardiac Allografts"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-10-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "404", "bibliographicPageStart": "401", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "\u4fe1\u5dde\u533b\u5b66\u96d1\u8a8c"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Monocyte chemoattractant protein (MCP)-1is known to be critical in activating T lymphocytes,mast cells,and other cells.Recent studies show that MCP-1plays pivotal roles in several inflammatory conditions including the acute phase of cardiac allograft rejection.However,the pathophysiological roles of MCP-1in the neointimal formation of chronically rejected heart grafts remain unclear.To clarify the roles of MCP-1 in such allografts, we performed immunohistochemistry to detect MCP-1 and vascular cell adhesion molecule (VCAM)-1 using a murine cardiac allograft transplantation model (DBA/2 hearts to B10. D2 recipient mice). Transplanted cardiac allografts were harvested at days 14 (n\uff1d5) and 60 (n\uff1d5). For the control study,isografts were used (n\uff1d5). Allografts harvested at day 14 demonstrated no arterial intimal thickening, while severe intimal thickening was observed in allografts harvested at day 60. MCP-1 and VCAM-1were observed in the vascular endothelium of rejected cardiac allografts at days14and 60,but were not observed in isografts. The expression of MCP-1 in the arteries was enhanced at day 14, but was decreased at day60.However,VCAM-1expression was increased at day60.These results indicate that the expression of MCP-1was enhanced prior to the development of intimal thickening and VCAM-1expression. 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