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Although considerable progress has been made in understanding and mapping the response of autoantibodies to Tg, much less is known about recognition of Tg by pathogenic T-cell in human diseases. To identify such reactions, we analyzed the proliferative responses of T-cells in the peripheral blood (PBMC) to Tg and to synthetic peptides. Nineteen patients with Graves\u0027 disease, 2 patients with chronic thyroiditis , and\u30005 normal subjects were studied. PBMC from 4 of the patients with Graves\u0027 disease reacted to Tg. Their reactivities to synthetic peptides were less than that to Tg. 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