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Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
http://hdl.handle.net/10091/17665
http://hdl.handle.net/10091/17665e154f02b-a11d-453f-973f-f4de6e7db0c8
| 名前 / ファイル | ライセンス | アクション |
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H24Kou944_Sasayama.pdf (360.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||
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| 公開日 | 2014-06-27 | |||||||||||||||||||||||||||
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| タイトル | Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder | |||||||||||||||||||||||||||
| 言語 | ||||||||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||||||||
| DOI | ||||||||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jpsychires.2012.12.001 | |||||||||||||||||||||||||||
| 関連名称 | 10.1016/j.jpsychires.2012.12.001 | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| タイプ | journal article | |||||||||||||||||||||||||||
| 著者 |
Sasayama, Daimei
× Sasayama, Daimei
× Hattori, Kotaro
× Wakabayashi, Chisato
× Teraishi, Toshiya
× Hori, Hiroaki
× Ota, Miho
× Yoshida, Sumiko
× Arima, Kunimasa
× Higuchi, Teruhiko
× Amano, Naoji
× Kunugi, Hiroshi
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| 出版者 | ||||||||||||||||||||||||||||
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD | |||||||||||||||||||||||||||
| 引用 | ||||||||||||||||||||||||||||
| 内容記述 | JOURNAL OF PSYCHIATRIC RESEARCH. 47(3):401-406 (2013) | |||||||||||||||||||||||||||
| 書誌情報 |
JOURNAL OF PSYCHIATRIC RESEARCH 巻 47, 号 3, p. 401-406, 発行日 2013-03 |
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| 内容記述 | ||||||||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||||||||
| 内容記述 | 信州大学博士（医学）・学位論文・平成25年3月31日授与（甲第944号）・篠山 大明 | |||||||||||||||||||||||||||
| 抄録 | ||||||||||||||||||||||||||||
| 内容記述 | Elevated peripheral levels of interleukin-6 (IL-6) are common findings in schizophrenia and depression. However, previous studies that measured cerebrospinal fluid (CSF) IL-6 levels in these disorders reported controversial results. The present study examined whether CSF IL-6 levels are altered in patients with schizophrenia and those with depression. Lumbar punctures were performed in 32 patients with schizophrenia, 30 with major depressive disorder (MDD), and 35 healthy controls. Serum samples were simultaneously collected from all subjects in the patient groups and from 32 of the control group. CSF and serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Both the patients with schizophrenia and MDD had significantly higher CSF IL-6 levels compared to the controls (schizophrenia: P = 0.0027; MDD: P = 0.012). IL-6 levels were significantly higher in the CSF than in the serum. No significant correlation was observed between CSF and serum IL-6 levels. The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded. (C) 2012 Elsevier Ltd. All rights reserved. | |||||||||||||||||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||||||||||
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Sasayama, Daimei, Hattori, Kotaro, Wakabayashi, Chisato, Teraishi, Toshiya, Hori, Hiroaki, Ota, Miho, Yoshida, Sumiko, Arima, Kunimasa, Higuchi, Teruhiko, Amano, Naoji, Kunugi, Hiroshi, 2013, Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder: PERGAMON-ELSEVIER SCIENCE LTD, 401–406 p.
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