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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder

http://hdl.handle.net/10091/17665
e154f02b-a11d-453f-973f-f4de6e7db0c8
名前 / ファイル ライセンス アクション
H24Kou944_Sasayama.pdf H24Kou944_Sasayama.pdf (360.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-27
タイトル
言語 en
タイトル Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Sasayama, Daimei

× Sasayama, Daimei

WEKO 17277

Sasayama, Daimei

Search repository
Hattori, Kotaro

× Hattori, Kotaro

WEKO 17278

Hattori, Kotaro

Search repository
Wakabayashi, Chisato

× Wakabayashi, Chisato

WEKO 17279

Wakabayashi, Chisato

Search repository
Teraishi, Toshiya

× Teraishi, Toshiya

WEKO 17280

Teraishi, Toshiya

Search repository
Hori, Hiroaki

× Hori, Hiroaki

WEKO 17281

Hori, Hiroaki

Search repository
Ota, Miho

× Ota, Miho

WEKO 17282

Ota, Miho

Search repository
Yoshida, Sumiko

× Yoshida, Sumiko

WEKO 17283

Yoshida, Sumiko

Search repository
Arima, Kunimasa

× Arima, Kunimasa

WEKO 17284

Arima, Kunimasa

Search repository
Higuchi, Teruhiko

× Higuchi, Teruhiko

WEKO 17285

Higuchi, Teruhiko

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Amano, Naoji

× Amano, Naoji

WEKO 17286

Amano, Naoji

Search repository
Kunugi, Hiroshi

× Kunugi, Hiroshi

WEKO 17287

Kunugi, Hiroshi

Search repository
出版者
出版者 PERGAMON-ELSEVIER SCIENCE LTD
引用
内容記述タイプ Other
内容記述 JOURNAL OF PSYCHIATRIC RESEARCH. 47(3):401-406 (2013)
書誌情報 JOURNAL OF PSYCHIATRIC RESEARCH

巻 47, 号 3, p. 401-406, 発行日 2013-03
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成25年3月31日授与(甲第944号)・篠山 大明
抄録
内容記述タイプ Abstract
内容記述 Elevated peripheral levels of interleukin-6 (IL-6) are common findings in schizophrenia and depression. However, previous studies that measured cerebrospinal fluid (CSF) IL-6 levels in these disorders reported controversial results. The present study examined whether CSF IL-6 levels are altered in patients with schizophrenia and those with depression. Lumbar punctures were performed in 32 patients with schizophrenia, 30 with major depressive disorder (MDD), and 35 healthy controls. Serum samples were simultaneously collected from all subjects in the patient groups and from 32 of the control group. CSF and serum IL-6 levels were determined by enzyme-linked immunosorbent assay. Both the patients with schizophrenia and MDD had significantly higher CSF IL-6 levels compared to the controls (schizophrenia: P = 0.0027; MDD: P = 0.012). IL-6 levels were significantly higher in the CSF than in the serum. No significant correlation was observed between CSF and serum IL-6 levels. The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded. (C) 2012 Elsevier Ltd. All rights reserved.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jpsychires.2012.12.001
関連名称
関連名称 10.1016/j.jpsychires.2012.12.001
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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