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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling

http://hdl.handle.net/10091/16847
c1766976-a090-414b-b85f-c60660686806
名前 / ファイル ライセンス アクション
H24Kou924_Hashimoto.pdf H24Kou924_Hashimoto.pdf (10.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-03-26
タイトル
言語 en
タイトル PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Hashimoto, Koji

× Hashimoto, Koji

WEKO 17467

Hashimoto, Koji

Search repository
Kamijo, Yuji

× Kamijo, Yuji

WEKO 17468

Kamijo, Yuji

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Nakajima, Takero

× Nakajima, Takero

WEKO 17469

Nakajima, Takero

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Harada, Makoto

× Harada, Makoto

WEKO 17470

Harada, Makoto

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 17471

Higuchi, Makoto

Search repository
Ehara, Takashi

× Ehara, Takashi

WEKO 17472

Ehara, Takashi

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Shigematsu, Hidekazu

× Shigematsu, Hidekazu

WEKO 17473

Shigematsu, Hidekazu

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Aoyama, Toshifumi

× Aoyama, Toshifumi

WEKO 17474

Aoyama, Toshifumi

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出版者
出版者 HINDAWI PUBLISHING CORPORATION
引用
内容記述タイプ Other
内容記述 PPAR Research. Volume 2012 (2012), Article ID 976089, 11 pages
書誌情報 PPAR RESEARCH

p. Article ID 976089, 発行日 2012
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第924号)・橋本幸始
抄録
内容記述タイプ Abstract
内容記述 The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions. Recently, we reported that PPAR alpha in activated mesangial cells exerted anti-inflammatory effects and that the deficiency of PPAR alpha resulted in high susceptibility to glomerulonephritis. To investigate whether PPAR alpha activation improves the disease activity of MsPGN, we examined the protective effects of a PPAR alpha agonist, clofibrate, in a well-established model of human MsPGN, anti-Thy1 nephritis, for the first time. This study demonstrated that pretreatment with clofibrate (via a 0.02% or 0.1% clofibrate-containing diet) continuously activated the glomerular PPAR alpha, which outweighed the PPAR alpha deterioration associated with the nephritic process. The PPAR alpha activation appeared to suppress the NF-kappa B signaling pathway in glomeruli by the induction of I kappa B alpha, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes. These findings suggest the antinephritic potential of PPAR alpha-related medicines against MsPGN. PPAR alpha-related medicines might be useful as a treatment option for CKD.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1687-4757
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12156341
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1155/2012/976089
関連名称
関連名称 10.1155/2012/976089
権利
権利情報 Copyright © 2012 Hashimoto Koji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cite
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000305020000001
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