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PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling
http://hdl.handle.net/10091/16847
http://hdl.handle.net/10091/16847c1766976-a090-414b-b85f-c60660686806
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
H24Kou924_Hashimoto.pdf (10.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-03-26 | |||||
| タイトル | ||||||
| タイトル | PPAR alpha Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-kappa B Signaling | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1155/2012/976089 | |||||
| 関連名称 | 10.1155/2012/976089 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hashimoto, Koji
× Hashimoto, Koji× Kamijo, Yuji× Nakajima, Takero× Harada, Makoto× Higuchi, Makoto× Ehara, Takashi× Shigematsu, Hidekazu× Aoyama, Toshifumi |
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| 出版者 | ||||||
| 出版者 | HINDAWI PUBLISHING CORPORATION | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PPAR Research. Volume 2012 (2012), Article ID 976089, 11 pages | |||||
| 書誌情報 |
PPAR RESEARCH p. Article ID 976089, 発行日 2012 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 信州大学博士（医学）・学位論文・平成24年3月31日授与（甲第924号）・橋本幸始 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions. Recently, we reported that PPAR alpha in activated mesangial cells exerted anti-inflammatory effects and that the deficiency of PPAR alpha resulted in high susceptibility to glomerulonephritis. To investigate whether PPAR alpha activation improves the disease activity of MsPGN, we examined the protective effects of a PPAR alpha agonist, clofibrate, in a well-established model of human MsPGN, anti-Thy1 nephritis, for the first time. This study demonstrated that pretreatment with clofibrate (via a 0.02% or 0.1% clofibrate-containing diet) continuously activated the glomerular PPAR alpha, which outweighed the PPAR alpha deterioration associated with the nephritic process. The PPAR alpha activation appeared to suppress the NF-kappa B signaling pathway in glomeruli by the induction of I kappa B alpha, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes. These findings suggest the antinephritic potential of PPAR alpha-related medicines against MsPGN. PPAR alpha-related medicines might be useful as a treatment option for CKD. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1687-4757 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12156341 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2012 Hashimoto Koji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cite | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000305020000001 | |||||
