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  1. 055 医学部附属病院
  2. 0551 学術論文

Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog

http://hdl.handle.net/10091/17651
http://hdl.handle.net/10091/17651
39b1b1a1-9c21-43f1-9143-73b67d7e6d82
名前 / ファイル ライセンス アクション
Initial_Pulmonary_Respiration_Causes_Massive_Diaphragm.pdf Initial_Pulmonary_Respiration_Causes_Massive_Diaphragm.pdf (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-20
タイトル
タイトル Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1038/srep02183
関連名称 10.1038/srep02183
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Nakamura, Akinori

× Nakamura, Akinori

en Nakamura, Akinori

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Kobayashi, Masanori

× Kobayashi, Masanori

en Kobayashi, Masanori

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Kuraoka, Mutsuki

× Kuraoka, Mutsuki

en Kuraoka, Mutsuki

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Yuasa, Katsutoshi

× Yuasa, Katsutoshi

en Yuasa, Katsutoshi

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Yugeta, Naoko

× Yugeta, Naoko

en Yugeta, Naoko

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Okada, Takashi

× Okada, Takashi

en Okada, Takashi

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Takeda, Shin'ichi

× Takeda, Shin'ichi

en Takeda, Shin'ichi

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出版者
出版者 NATURE PUBLISHING GROUP
引用
内容記述 SCIENTIFIC REPORTS. 3:2183 (2013)
書誌情報 SCIENTIFIC REPORTS

巻 3, p. 2183, 発行日 2013-07
抄録
内容記述 The molecular mechanism of muscle degeneration in a lethal muscle disorder Duchene muscular dystrophy (DMD) has not been fully elucidated. The dystrophic dog, a model of DMD, shows a high mortality rate with a marked increase in serum creatine kinase (CK) levels in the neonatal period. By measuring serum CK levels in cord and venous blood, we found initial pulmonary respiration resulted in massive diaphragm damage in the neonates and thereby lead to the high serum CK levels. Furthermore, molecular biological techniques revealed that osteopontin was prominently upregulated in the dystrophic diaphragm prior to the respiration, and that immediate-early genes (c-fos and egr-1) and inflammation/immune response genes (IL-6, IL-8, COX-2, and selectin E) were distinctly overexpressed after the damage by the respiration. Hence, we segregated dystrophic phases at the molecular level before and after mechanical damage. These molecules could be biomarkers of muscle damage and potential targets in pharmaceutical therapies.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ EISSN
収録物識別子 2045-2322
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/23851606
関連名称 23851606
権利
権利情報 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000321735200002
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