Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-06-20 |
タイトル |
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タイトル |
Mechanisms of CYP3A Induction by Glucocorticoids in Human Fetal Liver Cells |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.2133/dmpk.DMPK-12-NT-018 |
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関連名称 |
10.2133/dmpk.DMPK-12-NT-018 |
キーワード |
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主題 |
CYP3A, induction, glucocorticoid, human fetal liver cells, glucocorticoid receptor, small interfering RNA, specific small interfering RNA |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Matsunaga, Tamihide
Maruyama, Masataka
Matsubara, Tsutomu
Nagata, Kiyoshi
Yamazoe, Yasushi
Ohmori, Shigeru
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出版者 |
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出版者 |
JAPANESE SOC STUDY XENOBIOTICS |
引用 |
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内容記述 |
DRUG METABOLISM AND PHARMACOKINETICS. 27(6):653-657 (2012) |
書誌情報 |
DRUG METABOLISM AND PHARMACOKINETICS
巻 27,
号 6,
p. 653-657,
発行日 2012-12
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抄録 |
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内容記述 |
Human fetal liver (HFL) cells express major drug metabolic enzymes CYP3A4, CYP3A5 and CYP3A7. In the fetal hepatocytes, betamethasone and dexamethasone (DEX) markedly enhanced the expression levels of CYP3A4 and CYP3A7 mRNAs and slightly increased the expression level of CYP3A5 mRNA. Interestingly, a high correlation between the CYP3A induction ability and the intensity of anti-inflammatory effect was observed. Human glucocorticoid receptor (GR) small interfering RNA clearly attenuated the expression level of GR mRNA, and diminished the DEX-stimulated CYP3A4, CYP3A5 and CYP3A7 expression in HFL cells. These findings indicate that GR mediates the induction of CYP3A4 and CYP3A7 expression in human fetal hepatocytes as well as the CYP3A5. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1347-4367 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1162652X |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/22673009 |
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関連名称 |
22673009 |
権利 |
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権利情報 |
Copyright© 2012 The Japanese Society for the Study of Xenobiotics |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000312616800011 |