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Immunohistochemical staining for p57/Kip2, p53, p16, and Ki67 antigen was performed on paraffin-embedded tissue specimens obtained from 36 patients with astrocytoma. Expression of p57/Kip2, p53, p16, and Ki67 antigen was generally increased in association with the astrocytoma tumor grade. Expression of p16 was higher in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells (p \u003c 0.05). Expression of p53 also tended to be higher, but not to a statistically significant extent, in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells. These findings suggest that p57/Kip2 inhibits the growth of human astrocytomas, and may function in parallel with p16 and p53. However, p57/Kip2 is, by itself, insufficient to arrest the cellular proliferation of human astrocytomas. (C) 2009 Elsevier Ltd. 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Antigen p57/Kip2 as a potential negative regulator of human astrocytoma growth
http://hdl.handle.net/10091/16946
4ebcd076-fb22-444e-8f3b-26e2a9b219fe
名前 / ファイル | ライセンス | Actions | |
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item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-23 | |||||
タイトル | ||||||
タイトル | Antigen p57/Kip2 as a potential negative regulator of human astrocytoma growth | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Astrocytoma | |||||
キーワード | ||||||
主題 | Cell proliferation | |||||
キーワード | ||||||
主題 | p16 | |||||
キーワード | ||||||
主題 | p57/Kip2 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Akaishi, Kotaro
× Akaishi, Kotaro× Nakayama, Jun× Sakai, Keiichi× Kobayashi, Tatsuya× Rutka, James T |
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信州大学研究者総覧へのリンク | ||||||
Nakayama, Jun | ||||||
http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | ||||||
出版者 | ||||||
出版者 | ELSEVIER SCI LTD | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF CLINICAL NEUROSCIENCE. 16(12):1615-1618 (2009) | |||||
書誌情報 |
JOURNAL OF CLINICAL NEUROSCIENCE 巻 16, 号 12, p. 1615-1618, 発行日 2009-12 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study was performed to determine the relationship between p57/Kip2 and the growth of human astrocytomas. Immunohistochemical staining for p57/Kip2, p53, p16, and Ki67 antigen was performed on paraffin-embedded tissue specimens obtained from 36 patients with astrocytoma. Expression of p57/Kip2, p53, p16, and Ki67 antigen was generally increased in association with the astrocytoma tumor grade. Expression of p16 was higher in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells (p < 0.05). Expression of p53 also tended to be higher, but not to a statistically significant extent, in patients whose tumors express p57/Kip2 in greater than 10% of tumor cells. These findings suggest that p57/Kip2 inhibits the growth of human astrocytomas, and may function in parallel with p16 and p53. However, p57/Kip2 is, by itself, insufficient to arrest the cellular proliferation of human astrocytomas. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0967-5868 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10958444 | |||||
PubMed | ||||||
関連識別子 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=19822429 | |||||
関連名称 | ||||||
関連名称 | 19822429 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.jocn.2009.05.007 | |||||
関連名称 | ||||||
関連名称 | 10.1016/j.jocn.2009.05.007 | |||||
権利 | ||||||
権利情報 | Copyright© 2009 Elsevier Ltd. | |||||
著者版フラグ | ||||||
値 | author | |||||
WoS | ||||||
Web of Science | ||||||
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271917800017 |