Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-04-01 |
タイトル |
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タイトル |
Genetic background of autoimmune hepatitis in Japan |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1007/s00535-010-0333-2 |
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関連名称 |
10.1007/s00535-010-0333-2 |
キーワード |
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主題 |
Autoimmune hepatitis, Genome-wide association study, Human leukocyte antigen, Single nucleotide polymorphisms, Tumor necrosis factor |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Yoshizawa, Kaname
Umemura, Takeji
Ota, Masao
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信州大学研究者総覧へのリンク |
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氏名 |
Umemura, Takeji |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ymSpgpkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Ota, Masao |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.ZefVOFkh.html |
出版者 |
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出版者 |
SPRINGER TOKYO |
引用 |
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内容記述 |
JOURNAL OF GASTROENTEROLOGY. 46(1):42-47 (2011) |
書誌情報 |
JOURNAL OF GASTROENTEROLOGY
巻 46,
号 1,
p. 42-47,
発行日 2011-01
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抄録 |
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内容記述 |
Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic beta chain of the HLA-DR antigen. However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0944-1174 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10988015 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20957499 |
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関連名称 |
20957499 |
権利 |
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権利情報 |
The final publication is available at www.springerlink.com |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000284646400007 |