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Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic beta chain of the HLA-DR antigen. However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yoshizawa,  Kaname", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umemura,  Takeji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ota,  Masao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "22397", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Genetic_background_autoimmune_hepatitis_Japan.pdf", "filesize": [{"value": "87.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 87000.0, "url": {"label": "Genetic_background_autoimmune_hepatitis_Japan.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/8067/files/Genetic_background_autoimmune_hepatitis_Japan.pdf"}, "version_id": "5219aec4-48b4-4d3f-85b2-149a85890d2f"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Autoimmune hepatitis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genome-wide association study", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Human leukocyte antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Single nucleotide polymorphisms", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumor necrosis factor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genetic background of autoimmune hepatitis in Japan", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Genetic background of autoimmune hepatitis in Japan", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["882/883"], "permalink_uri": "http://hdl.handle.net/10091/16882", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-04-01"}, "publish_date": "2013-04-01", "publish_status": "0", "recid": "8067", "relation": {}, "relation_version_is_last": true, "title": ["Genetic background of autoimmune hepatitis in Japan"], "weko_shared_id": -1}