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Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R
http://hdl.handle.net/10091/10765
http://hdl.handle.net/10091/107655b30985a-bd3a-455f-8be9-b22ef4fa0f33
名前 / ファイル | ライセンス | アクション |
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characterization_cellular_immunostimulating_Peptide.pdf (623.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-15 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3177/jnsv.55.428 | |||||
関連名称 | 10.3177/jnsv.55.428 | |||||
キーワード | ||||||
主題 | glycinin G4, Peptidase R, cellular immunostimulation, glutamine-rich peptide, cytotoxic activity | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Egusa, Shintaro
× Egusa, Shintaro× Otani, Hajime |
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出版者 | ||||||
出版者 | CENTER ACADEMIC PUBL JAPAN | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | |||||
書誌情報 |
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 巻 55, 号 5, p. 428-433, 発行日 2009-10 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An immunostimulating glutamine-rich peptide was purified from a soybean protein fraction digested with Peptidase R produced by Rhizopus oryzae (Ro-digest) by a combination of SP-Sepharose column chromatography and reversed-phase high-performance liquid chromatography. The purified peptide was supposed to be located at or near the glutamine-rich region 202 to 222 of the glycinin G4 subunit. The peptide significantly increased the number of CD8(+), CD11b(+), and CD49b(+) cells in C3H/HeN mouse spleen cell cultures, while 2 chemically synthesized glutamine-rich peptides corresponding to residues 202 to 213 (QQQQQQKSHGGR) and residues 214 to 225 (KQGQHQQEEEEE) of the glycinin G4 subunit increased the number of interleukin (IL)-12(+)CD11b(+) cells. The peptide 202-213 also significantly increased the number of CD49b(+), IL-2(+)CD4(+), and interferon-gamma(+)CD4(+) cells and stimulated the cytotoxic activity of spleen cells toward the human erythroleukemia cell line K562. These results indicate that the glutamine-rich region of the soybean glycinin G4 subunit stimulates the cellular immune system in mouse spleen cell cultures. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0301-4800 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00703822 | |||||
異版である | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://ci.nii.ac.jp/naid/10025972201/ | |||||
権利 | ||||||
権利情報 | Copyright (c) 2009 by the Center for Academic Publications Japan | |||||
権利 | ||||||
権利情報 | 日本ビタミン学会, 日本栄養・食糧学会 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271305900008 |