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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R

http://hdl.handle.net/10091/10765
5b30985a-bd3a-455f-8be9-b22ef4fa0f33
名前 / ファイル ライセンス アクション
characterization_cellular_immunostimulating_Peptide.pdf characterization_cellular_immunostimulating_Peptide.pdf (623.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-11-15
タイトル
言語 en
タイトル Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R
言語
言語 eng
キーワード
主題Scheme Other
主題 glycinin G4
キーワード
主題Scheme Other
主題 Peptidase R
キーワード
主題Scheme Other
主題 cellular immunostimulation
キーワード
主題Scheme Other
主題 glutamine-rich peptide
キーワード
主題Scheme Other
主題 cytotoxic activity
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Egusa, Shintaro

× Egusa, Shintaro

WEKO 32753

Egusa, Shintaro

Search repository
Otani, Hajime

× Otani, Hajime

WEKO 32754

Otani, Hajime

Search repository
出版者
出版者 CENTER ACADEMIC PUBL JAPAN
引用
内容記述タイプ Other
内容記述 JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
書誌情報 JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

巻 55, 号 5, p. 428-433, 発行日 2009-10
抄録
内容記述タイプ Abstract
内容記述 An immunostimulating glutamine-rich peptide was purified from a soybean protein fraction digested with Peptidase R produced by Rhizopus oryzae (Ro-digest) by a combination of SP-Sepharose column chromatography and reversed-phase high-performance liquid chromatography. The purified peptide was supposed to be located at or near the glutamine-rich region 202 to 222 of the glycinin G4 subunit. The peptide significantly increased the number of CD8(+), CD11b(+), and CD49b(+) cells in C3H/HeN mouse spleen cell cultures, while 2 chemically synthesized glutamine-rich peptides corresponding to residues 202 to 213 (QQQQQQKSHGGR) and residues 214 to 225 (KQGQHQQEEEEE) of the glycinin G4 subunit increased the number of interleukin (IL)-12(+)CD11b(+) cells. The peptide 202-213 also significantly increased the number of CD49b(+), IL-2(+)CD4(+), and interferon-gamma(+)CD4(+) cells and stimulated the cytotoxic activity of spleen cells toward the human erythroleukemia cell line K562. These results indicate that the glutamine-rich region of the soybean glycinin G4 subunit stimulates the cellular immune system in mouse spleen cell cultures.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0301-4800
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00703822
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.3177/jnsv.55.428
関連名称
関連名称 10.3177/jnsv.55.428
異版である
関連タイプ isVersionOf
関連識別子
識別子タイプ URI
関連識別子 http://ci.nii.ac.jp/naid/10025972201/
権利
権利情報 Copyright (c) 2009 by the Center for Academic Publications Japan
権利
権利情報 日本ビタミン学会, 日本栄養・食糧学会
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271305900008
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