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Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R
http://hdl.handle.net/10091/10765
http://hdl.handle.net/10091/107655b30985a-bd3a-455f-8be9-b22ef4fa0f33
| 名前 / ファイル | ライセンス | アクション |
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characterization_cellular_immunostimulating_Peptide.pdf (623.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2010-11-15 | |||||||||
| タイトル | ||||||||||
| タイトル | Characterization of a Cellular Immunostimulating Peptide from a Soybean Protein Fraction Digested with Peptidase R | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| DOI | ||||||||||
| 関連識別子 | https://doi.org/10.3177/jnsv.55.428 | |||||||||
| 関連名称 | 10.3177/jnsv.55.428 | |||||||||
| キーワード | ||||||||||
| 主題 | glycinin G4, Peptidase R, cellular immunostimulation, glutamine-rich peptide, cytotoxic activity | |||||||||
| 資源タイプ | ||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| タイプ | journal article | |||||||||
| 著者 |
Egusa, Shintaro
× Egusa, Shintaro
× Otani, Hajime
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| 出版者 | ||||||||||
| 出版者 | CENTER ACADEMIC PUBL JAPAN | |||||||||
| 引用 | ||||||||||
| 内容記述 | JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | |||||||||
| 書誌情報 |
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 巻 55, 号 5, p. 428-433, 発行日 2009-10 |
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| 抄録 | ||||||||||
| 内容記述 | An immunostimulating glutamine-rich peptide was purified from a soybean protein fraction digested with Peptidase R produced by Rhizopus oryzae (Ro-digest) by a combination of SP-Sepharose column chromatography and reversed-phase high-performance liquid chromatography. The purified peptide was supposed to be located at or near the glutamine-rich region 202 to 222 of the glycinin G4 subunit. The peptide significantly increased the number of CD8(+), CD11b(+), and CD49b(+) cells in C3H/HeN mouse spleen cell cultures, while 2 chemically synthesized glutamine-rich peptides corresponding to residues 202 to 213 (QQQQQQKSHGGR) and residues 214 to 225 (KQGQHQQEEEEE) of the glycinin G4 subunit increased the number of interleukin (IL)-12(+)CD11b(+) cells. The peptide 202-213 also significantly increased the number of CD49b(+), IL-2(+)CD4(+), and interferon-gamma(+)CD4(+) cells and stimulated the cytotoxic activity of spleen cells toward the human erythroleukemia cell line K562. These results indicate that the glutamine-rich region of the soybean glycinin G4 subunit stimulates the cellular immune system in mouse spleen cell cultures. | |||||||||
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| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0301-4800 | |||||||||
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| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00703822 | |||||||||
| 異版である | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://ci.nii.ac.jp/naid/10025972201/ | |||||||||
| 権利 | ||||||||||
| 権利情報 | Copyright (c) 2009 by the Center for Academic Publications Japan | |||||||||
| 権利 | ||||||||||
| 権利情報 | 日本ビタミン学会, 日本栄養・食糧学会 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
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| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000271305900008 | |||||||||
