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Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery
http://hdl.handle.net/10091/17824
http://hdl.handle.net/10091/178245711c26c-4b99-41a8-ad7a-89492cbec6a0
名前 / ファイル | ライセンス | アクション |
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089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf (358.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-08-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.4236/jbnb.2011.23025 | |||||
関連名称 | 10.4236/jbnb.2011.23025 | |||||
キーワード | ||||||
主題 | Self-Assembly, Amphiphilic, Nanoparticles, POSS, Insulin, Oral Delivery | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kim, Kyu-Oh
× Kim, Kyu-Oh× Akada, Yaeko× Wei, Kai× Kim, Byoung-Suhk× Kim, Ick-Soo |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Kim, Ick-Soo | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html | |||||
出版者 | ||||||
出版者 | Scientific Research | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011) | |||||
書誌情報 |
Journal of Biomaterials and Nanobiotechnology 巻 2, p. 201-206, 発行日 2011-07 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2158-7027 | |||||
権利 | ||||||
権利情報 | Copyright© 2014 by authors and Scientific Research Publishing Inc. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |