Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2014-08-25 |
タイトル |
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タイトル |
Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.4236/jbnb.2011.23025 |
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関連名称 |
10.4236/jbnb.2011.23025 |
キーワード |
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主題 |
Self-Assembly, Amphiphilic, Nanoparticles, POSS, Insulin, Oral Delivery |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Kim, Kyu-Oh
Akada, Yaeko
Wei, Kai
Kim, Byoung-Suhk
Kim, Ick-Soo
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信州大学研究者総覧へのリンク |
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氏名 |
Kim, Ick-Soo |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html |
出版者 |
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出版者 |
Scientific Research |
引用 |
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内容記述 |
Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011) |
書誌情報 |
Journal of Biomaterials and Nanobiotechnology
巻 2,
p. 201-206,
発行日 2011-07
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抄録 |
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内容記述 |
In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2158-7027 |
権利 |
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権利情報 |
Copyright© 2014 by authors and Scientific Research Publishing Inc. |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |