{"_buckets": {"deposit": "73baefb1-955d-4139-812d-23440a8cbddb"}, "_deposit": {"id": "13310", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "13310"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00013310", "sets": ["1309:1310"]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-07", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "206", "bibliographicPageStart": "201", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "Journal of Biomaterials and Nanobiotechnology"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7\uff08\u30b3\u30f3\u30c6\u30f3\u30c4\u306e\u7a2e\u985e\uff09", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "\u5f15\u7528", "attribute_value_mlt": [{"subitem_description": "Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "\u4fe1\u5dde\u5927\u5b66\u7814\u7a76\u8005\u7dcf\u89a7\u3078\u306e\u30ea\u30f3\u30af", "attribute_value_mlt": [{"subitem_link_text": "Kim, Ick-Soo", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html"}]}, "item_6_publisher_4": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Scientific Research"}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.4236/jbnb.2011.23025"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.4236/jbnb.2011.23025", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright\u00a9 2014 by authors and Scientific Research Publishing Inc."}]}, "item_6_select_64": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2158-7027", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2158-7027", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kim,  Kyu-Oh"}], "nameIdentifiers": [{"nameIdentifier": "40324", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akada,  Yaeko"}], "nameIdentifiers": [{"nameIdentifier": "40325", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wei,  Kai"}], "nameIdentifiers": [{"nameIdentifier": "40326", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kim,  Byoung-Suhk"}], "nameIdentifiers": [{"nameIdentifier": "40327", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kim,  Ick-Soo"}], "nameIdentifiers": [{"nameIdentifier": "40328", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf", "filesize": [{"value": "358.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 358400.0, "url": {"label": "089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/13310/files/089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf"}, "version_id": "85bf731f-47e7-4f6b-adc5-488d5b1d5fba"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Self-Assembly", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Amphiphilic", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nanoparticles", "subitem_subject_scheme": "Other"}, {"subitem_subject": "POSS", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Insulin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oral Delivery", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery"}]}, "item_type_id": "6", "owner": "1", "path": ["1309/1310"], "permalink_uri": "http://hdl.handle.net/10091/17824", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-08-25"}, "publish_date": "2014-08-25", "publish_status": "0", "recid": "13310", "relation": {}, "relation_version_is_last": true, "title": ["Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery"], "weko_shared_id": null}