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  1. 080 繊維学部
  2. 0801 学術論文

Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery

http://hdl.handle.net/10091/17824
5711c26c-4b99-41a8-ad7a-89492cbec6a0
名前 / ファイル ライセンス アクション
089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf 089_Self-Assembled_Core-Shell_Polye_thylene_glycol-POSS.pdf (358.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-08-25
タイトル
言語 en
タイトル Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery
言語
言語 eng
キーワード
主題Scheme Other
主題 Self-Assembly
キーワード
主題Scheme Other
主題 Amphiphilic
キーワード
主題Scheme Other
主題 Nanoparticles
キーワード
主題Scheme Other
主題 POSS
キーワード
主題Scheme Other
主題 Insulin
キーワード
主題Scheme Other
主題 Oral Delivery
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Kim, Kyu-Oh

× Kim, Kyu-Oh

WEKO 40324

Kim, Kyu-Oh

Search repository
Akada, Yaeko

× Akada, Yaeko

WEKO 40325

Akada, Yaeko

Search repository
Wei, Kai

× Wei, Kai

WEKO 40326

Wei, Kai

Search repository
Kim, Byoung-Suhk

× Kim, Byoung-Suhk

WEKO 40327

Kim, Byoung-Suhk

Search repository
Kim, Ick-Soo

× Kim, Ick-Soo

WEKO 40328

Kim, Ick-Soo

Search repository
信州大学研究者総覧へのリンク
氏名 Kim, Ick-Soo
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyCjFkV.html
出版者
出版者 Scientific Research
引用
内容記述タイプ Other
内容記述 Journal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)
書誌情報 Journal of Biomaterials and Nanobiotechnology

巻 2, p. 201-206, 発行日 2011-07
抄録
内容記述タイプ Abstract
内容記述 In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 2158-7027
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.4236/jbnb.2011.23025
関連名称
関連名称 10.4236/jbnb.2011.23025
権利
権利情報 Copyright© 2014 by authors and Scientific Research Publishing Inc.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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