Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2012-12-10 |
タイトル |
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タイトル |
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9 |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2010.02.110 |
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関連名称 |
10.1016/j.bbrc.2010.02.110 |
キーワード |
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主題 |
IL-33, CpG-ODN, TLR9, IL-1 superfamily, Streptococcus thermophilus |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Shimosato, Takeshi
Fujimoto, Megumi
Tohno, Masanori
Sato, Takashi
Tateo, Mariko
Otani, Hajime
Kitazawa, Haruki
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信州大学研究者総覧へのリンク |
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氏名 |
Shimosato, Takeshi |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
出版者 |
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出版者 |
ACADEMIC PRESS INC ELSEVIER SCIENCE |
引用 |
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内容記述 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010) |
書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
巻 394,
号 1,
p. 81-86,
発行日 2010-03-26
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抄録 |
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内容記述 |
We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-291X |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00564395 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20178773/ |
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関連名称 |
20178773 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000276474800015 |