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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9

http://hdl.handle.net/10091/16135
24c7b6f5-3f17-4cb3-b2ea-a64234b1da55
名前 / ファイル ライセンス アクション
CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf (401.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-10
タイトル
言語 en
タイトル CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
言語
言語 eng
キーワード
主題Scheme Other
主題 IL-33
キーワード
主題Scheme Other
主題 CpG-ODN
キーワード
主題Scheme Other
主題 TLR9
キーワード
主題Scheme Other
主題 IL-1 superfamily
キーワード
主題Scheme Other
主題 Streptococcus thermophilus
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shimosato, Takeshi

× Shimosato, Takeshi

WEKO 32551

Shimosato, Takeshi

Search repository
Fujimoto, Megumi

× Fujimoto, Megumi

WEKO 32552

Fujimoto, Megumi

Search repository
Tohno, Masanori

× Tohno, Masanori

WEKO 32553

Tohno, Masanori

Search repository
Sato, Takashi

× Sato, Takashi

WEKO 32554

Sato, Takashi

Search repository
Tateo, Mariko

× Tateo, Mariko

WEKO 32555

Tateo, Mariko

Search repository
Otani, Hajime

× Otani, Hajime

WEKO 32556

Otani, Hajime

Search repository
Kitazawa, Haruki

× Kitazawa, Haruki

WEKO 32557

Kitazawa, Haruki

Search repository
信州大学研究者総覧へのリンク
氏名 Shimosato, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
出版者
出版者 ACADEMIC PRESS INC ELSEVIER SCIENCE
引用
内容記述タイプ Other
内容記述 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010)
書誌情報 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

巻 394, 号 1, p. 81-86, 発行日 2010-03-26
抄録
内容記述タイプ Abstract
内容記述 We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-291X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00564395
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=20178773
関連名称
関連名称 20178773
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.bbrc.2010.02.110
関連名称
関連名称 10.1016/j.bbrc.2010.02.110
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000276474800015
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