{"_buckets": {"deposit": "4fd85a7e-c5c8-4ca2-ad83-9d74c79b4c5c"}, "_deposit": {"id": "10290", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10290"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00010290", "sets": ["1016:1017"]}, "author_link": ["32551", "32552", "32553", "32554", "32555", "32556", "32557"], "item_1628147817048": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-03-26", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "86", "bibliographicPageStart": "81", "bibliographicVolumeNumber": "394", "bibliographic_titles": [{"bibliographic_title": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS"}]}]}, "item_6_description_20": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. 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Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods. (C) 2010 Elsevier Inc. All rights reserved."}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimosato,  Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "32551", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimoto,  Megumi"}], "nameIdentifiers": [{"nameIdentifier": "32552", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tohno,  Masanori"}], "nameIdentifiers": [{"nameIdentifier": "32553", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato,  Takashi"}], "nameIdentifiers": [{"nameIdentifier": "32554", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tateo,  Mariko"}], "nameIdentifiers": [{"nameIdentifier": "32555", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Otani,  Hajime"}], "nameIdentifiers": [{"nameIdentifier": "32556", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitazawa,  Haruki"}], "nameIdentifiers": [{"nameIdentifier": "32557", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf", "filesize": [{"value": "401.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 401000.0, "url": {"label": "CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/10290/files/CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf"}, "version_id": "9794ef0b-e2b8-4c5b-8b7a-09b4c9f6a425"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "IL-33", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CpG-ODN", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TLR9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-1 superfamily", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Streptococcus thermophilus", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["1016/1017"], "permalink_uri": "http://hdl.handle.net/10091/16135", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-12-10"}, "publish_date": "2012-12-10", "publish_status": "0", "recid": "10290", "relation": {}, "relation_version_is_last": true, "title": ["CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9"], "weko_shared_id": -1}