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Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods. (C) 2010 Elsevier Inc. 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CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
http://hdl.handle.net/10091/16135
http://hdl.handle.net/10091/1613524c7b6f5-3f17-4cb3-b2ea-a64234b1da55
名前 / ファイル | ライセンス | アクション |
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CpG_oligodeoxynucleotides_induce_strong_up-regulation.pdf (401.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-12-10 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9 | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.bbrc.2010.02.110 | |||||
関連名称 | 10.1016/j.bbrc.2010.02.110 | |||||
キーワード | ||||||
主題 | IL-33, CpG-ODN, TLR9, IL-1 superfamily, Streptococcus thermophilus | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shimosato, Takeshi
× Shimosato, Takeshi× Fujimoto, Megumi× Tohno, Masanori× Sato, Takashi× Tateo, Mariko× Otani, Hajime× Kitazawa, Haruki |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Shimosato, Takeshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html | |||||
出版者 | ||||||
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 394(1):81-86 (2010) | |||||
書誌情報 |
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 巻 394, 号 1, p. 81-86, 発行日 2010-03-26 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously reported the strong immunostimulatory effects of a CpG oligodeoxynucleotide (ODN), designated MsST, from the lacZ gene of Streptococcus (S.) thermophilus ATCC19258. Here we show that 24 h of stimulation with MsST in mouse splenocytes and peritoneal macrophages strongly induces expression of interleukin (IL)-33, a cytokine in the IL-1 superfamily. Other IL-1 superfamily members, including IL-1 alpha, IL-1 beta and IL-18, are down-regulated after 24 h of stimulation of MsST. We also found that MsST-induced IL-33 mRNA expression is inhibited by the suppressive ODN A151, which can inhibit Toll-like receptor 9 (TLR9)-mediated responses. This is the first report to show that IL-33 can be induced by CpG ODNs. The strong induction of IL-33 by MsST suggests that it may be a potential therapeutic ODN for the treatment of inflammatory disease. The presence of a strong CpG ODN in S. thermophilus also suggests that the bacterium may be a good candidate as a starter culture for the development of new physiologically functional foods. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00564395 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20178773/ | |||||
関連名称 | 20178773 | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000276474800015 |