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Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity
http://hdl.handle.net/10091/840
http://hdl.handle.net/10091/8403528c4d1-a0fe-418e-a3eb-b00793739044
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v31n01_05.pdf (421.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
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| 公開日 | 2007-12-28 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | glucosamine, Angiotensin I converting enzyme, inhibitor | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | departmental bulletin paper | |||||||||||||
| その他（別言語等）のタイトル | ||||||||||||||
| その他のタイトル | Ｎ置換グルコサミン誘導体の合成とそれらのアンジオテンシン I 変換酵素阻害能 | |||||||||||||
| 言語 | ja | |||||||||||||
| 著者 |
Kawakami, A
× Kawakami, A
× Kayahara, H
× Ajiro, H
× Tadasa, K
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| 出版者 | ||||||||||||||
| 出版者 | 信州大学農学部 | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | 信州大学農学部紀要. 31(1): 45-54 (1994) | |||||||||||||
| 書誌情報 |
信州大学農学部紀要 巻 31, 号 1, p. 45-54, 発行日 1994-08-31 |
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| 抄録 | ||||||||||||||
| 内容記述 | Inhibitory activity of glucosamine derivatives against angiotensin I converting enzyme (ACE) was investigated. Many N-substituted glucosamine derivatives were synthesized via 1,3,4,6-tetra-O-acetyl-glucosamine hydrochloride. Among them, N-(phenylalanyl-alanyl-prolyl)-glucosamine was found to be the most effective for ACE inhibition, and the half inhibitory concentrations (IC50_) was estimated as 300μM. Furthermore, N-(3,7-dimethyl-2(E/Z), 6-hexadien-carbonyl)-glucosamine and N-(p-dimethylamino benzoyl)-glucosamine were found to be effective for the inhibition of ACE, and their IC50 values were estimated as 5 mM and 8 mM, respectively. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0583-0621 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00121352 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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Cite as
Kawakami, A, Kayahara, H, Ajiro, H, Tadasa, K, 1994, Synthesis of N-Substituted Glucosamine Derivatives and Their Angiotensin I Converting Enzyme Inhibitory Activity: 信州大学農学部, 45–54 p.
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