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Synthesis of Butyl 1-p-Menthene-3-A.zido-4-Hydroxy-7-Carboxylate, the Synthetic Intermediate of Statine Analogue
http://hdl.handle.net/10091/2448
http://hdl.handle.net/10091/2448b265766e-a645-4fb3-9bab-0b098f7ce9c4
名前 / ファイル | ライセンス | アクション |
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Agriculture24-02-05.pdf (248.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-03-03 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Synthesis of Butyl 1-p-Menthene-3-A.zido-4-Hydroxy-7-Carboxylate, the Synthetic Intermediate of Statine Analogue | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | スタチン類縁体合成の中間体Buty1 1-P-Menthene-3-Azido-a-Hydroxy-7-Carboxylateの合成 | |||||
著者 |
SHIBATA, Hisao
× SHIBATA, Hisao× HASEGAWA, Taizo× KAYAHARA, Hiroshi |
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出版者 | ||||||
出版者 | 信州大学農学部 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州大学農学部紀要 24(2): 141-146(1988) | |||||
書誌情報 |
信州大学農学部紀要 巻 24, 号 2, p. 141-146, 発行日 1988-01-25 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Protease inhibitor, pepstatin is a pentapeptide which involves two unusual amino acid, statine (3S-hydroxy-4S-amino-6-methylheptanoic acid (I)). Pepstatin is known to inhibit renin in the hypertensive renin-angiotensin system and shown to suppress blood pressure strongly. The present paper deals with the simple and convenient synthesis of butyl 1-p-menthen-3-azido-4-hydroxy-7-carboxy late (III) in which III is one of the important intermediate leading to the isosteric isomer of statin, namely, p-menthan-3-amino-2-hydroxy-7-carboxylic acid (II). Further, the acid-catalysed isomerization is also discussed. | |||||
言語 | en | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0583-0621 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00121352 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |