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Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer
http://hdl.handle.net/10091/00019823
http://hdl.handle.net/10091/000198231cd8ad15-a00f-40de-beaf-8fb81eb93ba8
| 名前 / ファイル | ライセンス | アクション |
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Dual_Roles_of_Gastric_Gland_Mucin-specific_O-glycans.pdf (2.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2017-09-20 | |||||||
| タイトル | ||||||||
| タイトル | Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| DOI | ||||||||
| 関連識別子 | https://doi.org/10.1267/ahc.13034 | |||||||
| 関連名称 | 10.1267/ahc.13034 | |||||||
| キーワード | ||||||||
| 主題 | expression cloning, glycosyltransferase, H. pylori, knockout mouse, mucin histochemistry | |||||||
| 資源タイプ | ||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||
| タイプ | journal article | |||||||
| 著者 |
Nakayama, Jun
× Nakayama, Jun
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| 信州大学研究者総覧へのリンク | ||||||||
| 氏名 | Nakayama, Jun | |||||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.HCApHFkh.html | |||||||
| 出版者 | ||||||||
| 出版者 | JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY | |||||||
| 引用 | ||||||||
| 内容記述 | ACTA HISTOCHEMICA ET CYTOCHEMICA. 47(1):1-9 (2014) | |||||||
| 書誌情報 |
ACTA HISTOCHEMICA ET CYTOCHEMICA 巻 47, 号 1, p. 1-9, 発行日 2014 |
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| 抄録 | ||||||||
| 内容記述 | Gastric gland mucin is secreted from gland mucous cells, including pyloric gland cells and mucous neck cells located in the lower layer of the gastric mucosa. These mucins typically contain O-glycans carrying terminal alpha 1,4-linked N-acetylglucosamine residues (alpha GlcNAc) attached to the scaffold protein MUC6, and biosynthesis of the O-glycans is catalyzed by the glycosyltransferase, alpha 1,4-N-acetylglucosaminyltransferase (alpha 4GnT). We previously used expression cloning to isolate cDNA encoding alpha 4GnT, and then demonstrated that aGlcNAc functions as natural antibiotic against Helicobacter pylori, a microbe causing various gastric diseases including gastric cancer. More recently, it was shown that aGlcNAc serves as a tumor suppressor for differentiated-type adenocarcinoma. This review summarizes these findings and identifies dual roles for aGlcNAc in gastric cancer. | |||||||
| 資源タイプ（コンテンツの種類） | ||||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0044-5991 | |||||||
| 書誌レコードID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00508022 | |||||||
| PubMed | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/24761044 | |||||||
| 関連名称 | 24761044 | |||||||
| 権利 | ||||||||
| 権利情報 | © 2014 The Japan Society of Histochemistry and Cytochemistry | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| WoS | ||||||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000342658500001 | |||||||
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Cite as
Nakayama, Jun, 2014, Dual Roles of Gastric Gland Mucin-specific O-glycans in Prevention of Gastric Cancer: JAPAN SOC HISTOCHEMISTRY & CYTOCHEMISTRY, 1–9 p.
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