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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Methylxanthine Derivative-Rich Cacao Extract Suppresses Differentiation of Adipocytes through Downregulation of PPARγ and C/EBPs

http://hdl.handle.net/10091/0002000704
http://hdl.handle.net/10091/0002000704
38c57df1-4b78-4d4c-8ddb-23f7ae316e66
名前 / ファイル ライセンス アクション
JNSV64-2-151.pdf JNSV64-2-151.pdf
Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-01-27
タイトル
言語 en
タイトル Methylxanthine Derivative-Rich Cacao Extract Suppresses Differentiation of Adipocytes through Downregulation of PPARγ and C/EBPs
言語
言語 eng
キーワード
主題Scheme Other
主題 cacao
キーワード
主題Scheme Other
主題 methylxanthine derivatives
キーワード
主題Scheme Other
主題 PPARγ
キーワード
主題Scheme Other
主題 C/EBPs
キーワード
主題Scheme Other
主題 adipocyte differentiation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yamashita, Yoko

× Yamashita, Yoko

en Yamashita, Yoko

Search repository
Mitani, Takakazu

× Mitani, Takakazu

en Mitani, Takakazu

Search repository
Wang, Liuqing

× Wang, Liuqing

en Wang, Liuqing

Search repository
Ashida, Hitoshi

× Ashida, Hitoshi

en Ashida, Hitoshi

Search repository
信州大学研究者総覧へのリンク
氏名 三谷, 塁一
URL https://soar-rd.shinshu-u.ac.jp/profile/ja.ypcCPUkh.html
出版者
出版者 一般財団法人 学会誌刊行センター
引用
内容記述タイプ Other
内容記述 Journal of Nutritional Science and Vitaminology. 64(2): 151-160. (2018)
書誌情報 Journal of Nutritional Science and Vitaminology

巻 64, 号 2, p. 151-160, 発行日 2018-04-30
抄録
内容記述タイプ Abstract
内容記述 Abstract
Cacao extract (CE) consumption has beneficial effects on human health, such as lowering the risk of obesity. However, the underlying molecular mechanism for the anti-obesity effect of CE remains incompletely understood. Here, we used a 50% aqueous alcohol extract of cacao mass, which is rich in methylxanthine derivatives (about 11%) and poor in flavan-3-ols (less than 1%), and assessed the suppression effects of this extract on adipocyte differentiation to investigate the anti-obesity mechanism. CE dose-dependently decreased fat accumulation in 3T3-L1 cells without affecting cell viability. CE also dose-dependently decreased the protein and gene expression levels of two adipogenesis-related transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs). Moreover, CE decreased protein expression levels of sterol regulatory element-binding protein 1 (SREBP1) and its downstream fatty acid synthase (FAS), which was accompanied by the retained localization of SREBP1 in the cytoplasm of 3T3-L1 cells. After ICR mice were fed a diet containing 1% CE for 1 wk, their white adipose tissue weight was lower, whereas their brown adipose tissue weight was higher compared with those of control animals. Additionally, the protein expression levels of PPARγ, C/EBPs, SREBP1, and FAS in the white adipose tissue of these mice were also lower than those in control animals. In contrast, diet supplementation with CE induced higher levels of phosphorylated AMP-activated protein kinase (AMPK) and its downstream acetyl-CoA carboxylase. In conclusion, methylxanthine derivative-rich CE decreases fat accumulation in adipocytes by downregulating the expression of the adipocyte differentiation master regulators through the activation of AMPK.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ EISSN
収録物識別子 1881-7742
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12108939
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.3177/jnsv.64.151
関連名称 10.3177/jnsv.64.151
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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