Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2022-11-14 |
タイトル |
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タイトル |
Presence of Colistin- and Tigecycline-Resistant Klebsiella pneumoniae ST29 in Municipal Wastewater Influents in Japan |
言語 |
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言語 |
eng |
DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.1089/mdr.2020.0514 |
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関連名称 |
10.1089/mdr.2020.0514 |
キーワード |
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主題 |
colistin, tigecycline, mgrB, ramR, K. pneumoniae, WWTPs |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Hayashi, Wataru
Iimura, Masaki
Soga, Eiji
Koide, Shota
Izumi, Katsutoshi
Yoshida, Satoshi
Arakawa, Yoshichika
Nagano, Yukiko
Nagano, Noriyuki
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信州大学研究者総覧へのリンク |
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氏名 |
長野, 由紀子 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.OUAeumyC.html |
信州大学研究者総覧へのリンク |
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氏名 |
長野, 則之 |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.HULFumkh.html |
出版者 |
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出版者 |
Marry Ann |
引用 |
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内容記述 |
Microbial Drug Resistance 27(10) : 1433-1442(2021) |
書誌情報 |
Microbial Drug Resistance
巻 27,
号 10,
p. 1433-1442,
発行日 2021-10-14
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抄録 |
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内容記述 |
The aim of this study was to investigate the presence of colistin- and/or tigecycline-resistant Klebsiella spp. in influents from four wastewater treatment plants (WWTPs), which partly reflect the gut microbiome of human populations. Colistin- and tigecycline-resistant Klebsiella pneumoniae isolates (K30/ST29) were detected four times from the WWTP A during a period of 3 months. Disruptions of the mgrB and ramR genes by ISEc68 and ISKpn21, respectively, were identified in those four isolates. They also shared the IncL/M 86,197-bp plasmids carrying a bla(CTX-M-3) and Tn1548-associated armA [IS26-IntI1-dfrA12-gucF-aadA2-qacE Delta 1-sul1-ISCR1-ISEc28-armA-ISEc29-msr(E)-mph(E)-IS26]. Those isolates formed a distinct cluster within wgMLST clusters of ST29 K30 public reference strains of human origin and were unique due to harboring of Tn21-like mercury resistance operon transposons in addition to silver, copper, and arsenic resistance determinants. Five K. pneumoniae strains with different STs and 1 Klebsiella quasipneumoniae strain, exhibiting colistin resistance, were detected in WWTPs B, C, and D. For these isolates, disruptions of mgrB by ISEc68 (three isolates) or ISEcl1 (one isolate), insertion of IS2 in the mgrB promoter region (one isolate), and inactivation of MgrB by a nonsense mutation (one isolate) were identified. Close monitoring of these mcr-negative colistin- and/or tigecycline-resistant bacteria in wastewater influents is imperative to avoid further limiting of treatment options. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1931-8448 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11056498 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/33835858/ |
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関連名称 |
33835858 |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |