{"_buckets": {"deposit": "326007f3-906e-4aa1-b2ae-e014a1bcc42d"}, "_deposit": {"id": "2001238", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001238"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:02001238", "sets": ["462"]}, "author_link": [], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-06", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "131", "bibliographicPageStart": "124", "bibliographicVolumeNumber": "25", "bibliographic_titles": [{"bibliographic_title": "Journal of Global Antimicrobial Resistance"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: We determined the whole DNA sequences of plasmids carrying a rare extended-spectrum beta-lactamase gene (bla(TEM-61)) to precisely understand the spread of resistance among nosocomial Serratia marcescens populations. \u003cbr\u003eMethods: Twenty non-duplicate ceftazidime-resistant S. marcescens nosocomial isolates (ceftazidime MICs, 32 to \u003e128 mg/L) collected over 1 year were pulsotyped and nucleotide sequences of the bla(TEM-61) gene and its promoter region were determined. Twelve representative isolates were analysed by whole-genome sequencing. \u003cbr\u003eResults: The 20 isolates comprised two distinct pulsotypes: I (14 isolates) and II (6 isolates). They all contained the bla(TEM-61) gene. A polymorphism in the repeat number of a 15-nucleotide sequence (5\u0027-ATGTCATGATAATAA-3\u0027) was found in the promoter region of bla(TEM-61); two, three and four repeat units were found in 6,12 and 2 isolates, respectively. Single nucleotide polymorphism (SNP)-based phylogenetic analysis of 12 isolates revealed that 7 isolates of pulsotype I (12-44 SNP differences) and 5 isolates of pulsotype II (15-55 SNP differences) formed two distinct clusters of genotypes 1 and 2, respectively. All 12 isolates harboured a plasmid carrying the Tn1-bla(TEM-61) element, although they were slightly different in size (78 883 bp, 78 898 bp and 78 913 bp) owing to differences in the number of 15-bp repetitive sequences. A 42 542-bp broad-host-range plasmid carrying the Tn1-bla(TEM-61) element was also found in one of the isolates. Conclusions: We characterised a plasmid-encoded novel Tn1-bla(TEM-61) element and transposon-dependent mechanisms underlying the propagation of antibiotic resistance, together with repeated new polymorphic 15-bp units in the promoter of bla(TEM-61). (C) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Journal of Global Antimicrobial Resistance 25 : 124-131(2021)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "長野, 由紀子", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.OUAeumyC.html"}, {"subitem_link_text": "長野, 則之", "subitem_link_url": "https://soar-rd.shinshu-u.ac.jp/profile/ja.HULFumkh.html"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "33762209"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubmed.ncbi.nlm.nih.gov/33762209/", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1016/j.jgar.2021.03.010"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jgar.2021.03.010", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2213-7173", "subitem_source_identifier_type": "EISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2213-7173", "subitem_source_identifier_type": "EISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hayashi, Wataru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yoshida, Satoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Izumi, Katsutoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Koide, Shota", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Soga, Eiji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takizawa, Shino", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Arakawa, Yoshichika", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nagano, Yukiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nagano, Noriyuki", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-11-14"}], "download_preview_message": "", "file_order": 0, "filename": "18K08428_8.pdf", "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 0, "url": {"label": "18K08428_8.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/2001238/files/18K08428_8.pdf"}, "version_id": "465bb6f6-46df-4665-9765-a49b85dac8a0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Serratia marcescens", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nosocomial spread", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tn1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ceftazidime resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bla(TEM-61)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genomic characterisation and epidemiology of nosocomial Serratia marcescens isolates resistant to ceftazidime and their plasmids mediating rare bla TEM-61", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genomic characterisation and epidemiology of nosocomial Serratia marcescens isolates resistant to ceftazidime and their plasmids mediating rare bla TEM-61", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["462"], "permalink_uri": "http://hdl.handle.net/10091/0002001238", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-11-14"}, "publish_date": "2022-11-14", "publish_status": "0", "recid": "2001238", "relation": {}, "relation_version_is_last": true, "title": ["Genomic characterisation and epidemiology of nosocomial Serratia marcescens isolates resistant to ceftazidime and their plasmids mediating rare bla TEM-61"], "weko_shared_id": -1}
Genomic characterisation and epidemiology of nosocomial Serratia marcescens isolates resistant to ceftazidime and their plasmids mediating rare bla TEM-61
http://hdl.handle.net/10091/0002001238
http://hdl.handle.net/10091/0002001238