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MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results\u003cp id=\"luts12050-para-0003\"\u003eAt RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. 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MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results\u003cp id=\"luts12050-para-0003\"\u003eAt RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. 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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious Rats

http://hdl.handle.net/10091/00021613
http://hdl.handle.net/10091/00021613
a42ba06e-81c6-496d-bbb2-2e68e7606e22
名前 / ファイル ライセンス アクション
15K10622_05.pdf 15K10622_05.pdf (871.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-09-09
タイトル
言語 en
タイトル Pathways Involving Beta-3 Adrenergic Receptors Modulate Cold Stress-Induced Detrusor Overactivity in Conscious Rats
言語
言語 eng
キーワード
主題Scheme Other
主題 beta-3 adrenergic receptor
キーワード
主題Scheme Other
主題 cold stress
キーワード
主題Scheme Other
主題 detrusor overactivity
キーワード
主題Scheme Other
主題 lower urinary tract symptoms
キーワード
主題Scheme Other
主題 Sprague-Dawley rat
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Imamura, Tetsuya

× Imamura, Tetsuya

WEKO 108424

en Imamura, Tetsuya

Search repository
Ishizuka, Osamu

× Ishizuka, Osamu

WEKO 108425

en Ishizuka, Osamu

Search repository
Ogawa, Teruyuki

× Ogawa, Teruyuki

WEKO 108426

en Ogawa, Teruyuki

Search repository
Yamagishi, Takahiro

× Yamagishi, Takahiro

WEKO 108427

en Yamagishi, Takahiro

Search repository
Yokoyama, Hitoshi

× Yokoyama, Hitoshi

WEKO 108428

en Yokoyama, Hitoshi

Search repository
Minagawa, Tomonori

× Minagawa, Tomonori

WEKO 108429

en Minagawa, Tomonori

Search repository
Nakazawa, Masaki

× Nakazawa, Masaki

WEKO 108430

en Nakazawa, Masaki

Search repository
Nishizawa, Osamu

× Nishizawa, Osamu

WEKO 108431

en Nishizawa, Osamu

Search repository
信州大学研究者総覧へのリンク
氏名 Imamura, Tetsuya
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ypACOmyC.html
信州大学研究者総覧へのリンク
氏名 Ishizuka, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.gmfaHekh.html
信州大学研究者総覧へのリンク
氏名 Ogawa, Teruyuki
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.yhTUgpkh.html
信州大学研究者総覧へのリンク
氏名 Minagawa, Tomonori
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jCfagUkh.html
信州大学研究者総覧へのリンク
氏名 Nishizawa, Osamu
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WeyeWmyU.html
出版者
出版者 WILEY-BLACKWELL
引用
内容記述タイプ Other
内容記述 LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2014)
書誌情報 LUTS-LOWER URINARY TRACT SYMPTOMS

巻 7, 号 1, p. 50-55, 発行日 2014-03-02
抄録
内容記述タイプ Abstract
内容記述 ObjectiveTo investigate pathways involving beta-3 adrenergic receptors (ARs) in detrusor overactivity induced by cold stress, we determined if the beta-3 AR agonist CL316243 could modulate the cold stress-induced detrusor overactivity in normal rats. MethodsTwodays prior to cystometric investigations, the bladders of 10-week-old female Sprague-Dawley rats were cannulated. Cystometric measurements of the unanesthetized, unrestricted rats were taken to estimate baseline values at room temperature (RT, 272 degrees C) for 20min. They were then intravenously administered vehicle, 0.1, or 1.0mg/kg CL316243 (n=6 in each group). Fiveminutes after the treatments, they were gently and quickly transferred to the low temperature (LT, 42 degrees C) room for 40min where the cystometric measurements were again made. Afterward, the rats were returned to RT for final cystometric measurements. The cystometric effects of CL316243 were also measured at RT (n=6 in each group). Results<p id="luts12050-para-0003">At RT, both low and high dose of CL316243 decreased basal and micturition pressure while the high dose (1.0mg/kg) significantly increased voiding interval and bladder capacity. During LT exposure, the high dose of CL316243 partially reduced cold stress-induced detrusor overactivity characterized by increased basal pressure and urinary frequency. The high drug dose also significantly inhibited the decreases of both voiding interval and bladder capacity compared to the vehicle- and low dose (0.1mg/kg)-treated rats. Conclusion<p id="luts12050-para-0004">A high dose of the beta-3 agonist CL316243 could modulate cold stress-induced detrusor overactivity. Therefore, one of the mechanisms in cold stress-induced detrusor overactivity includes a pathway involving beta-3 ARs.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 1757-5664
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12809467
PubMed
識別子タイプ PMID
関連識別子 https://www.ncbi.nlm.nih.gov/pubmed/26663652
関連名称 26663652
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/luts.12050
関連名称 10.1111/luts.12050
権利
権利情報 This is the peer reviewed version of the following article: LUTS-LOWER URINARY TRACT SYMPTOMS.7(1):50-55(2015), which has been published in final form at [https://doi.org/10.1111/luts.12050]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000348738700009
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