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Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions
http://hdl.handle.net/10091/16260
http://hdl.handle.net/10091/162609e150938-3fda-43b5-833f-48b4a7700745
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Multiple_roles_PPAR_alpha_brown_adipose_tissue.pdf (5.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-02-13 | |||||
| タイトル | ||||||
| タイトル | Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/j.1365-2443.2009.01368.x | |||||
| 関連名称 | 10.1111/j.1365-2443.2009.01368.x | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Komatsu, Makiko
× Komatsu, Makiko× Tong, Yuhong× Li, Yufeng× Nakajima, Takero× Li, Gang× Hu, Rui× Sugiyama, Eiko× Kamijo, Yuji× Tanaka, Naoki× Hara, Atsushi× Aoyama, Toshifumi |
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| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Nakajima, Takero | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html | |||||
| 信州大学研究者総覧へのリンク | ||||||
| 表示名 | Kamijo, Yuji | |||||
| URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html | |||||
| 出版者 | ||||||
| 出版者 | WILEY-BLACKWELL PUBLISHING, INC | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | GENES TO CELLS. 15(2):91-100 (2010) | |||||
| 書誌情報 |
GENES TO CELLS 巻 15, 号 2, p. 91-100, 発行日 2010-02 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a member of the nuclear receptor family, regulating fatty acid degradation in many organs. Two-dimensional SDS-PAGE of brown adipose tissue (BAT) from PPAR alpha-null mice produced a higher-density spot. Proteomic analysis indicated that the protein was pyruvate dehydrogenase beta (PDH beta). To observe PDH beta regulation in BAT, the organ was stimulated by long-term cold exposure, and the activities of associated enzymes were investigated. Histological and biochemical analyses of BAT showed a significant decrease in the triglyceride content in wild-type mice and some degree of decrease in PPAR alpha-null mice on cold exposure. Analyses of molecules related to glucose metabolism showed that the expression of PDH beta is under PPAR alpha-specific regulation, and that glucose degradation ability may decrease on cold exposure. In contrast, analyses of molecules related to fatty acid metabolism showed that numerous PPAR alpha/gamma target molecules are induced on cold exposure, and that fatty acid degradation ability in wild-type mice is markedly enhanced and also increases to same degree in PPAR alpha-null mice on cold exposure. Thus, this study proposes novel and multiple roles of PPAR alpha in BAT. | |||||
| 資源タイプ（コンテンツの種類） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Article | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1356-9597 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11078945 | |||||
| PubMed | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20002497 | |||||
| 関連名称 | 20002497 | |||||
| 権利 | ||||||
| 権利情報 | The definitive version is available at www3.intersience.wiley.com | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| WoS | ||||||
| 表示名 | Web of Science | |||||
| URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274177800001 | |||||
