Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-02-13 |
タイトル |
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タイトル |
Multiple roles of PPAR alpha in brown adipose tissue under constitutive and cold conditions |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1111/j.1365-2443.2009.01368.x |
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関連名称 |
10.1111/j.1365-2443.2009.01368.x |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Komatsu, Makiko
Tong, Yuhong
Li, Yufeng
Nakajima, Takero
Li, Gang
Hu, Rui
Sugiyama, Eiko
Kamijo, Yuji
Tanaka, Naoki
Hara, Atsushi
Aoyama, Toshifumi
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信州大学研究者総覧へのリンク |
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氏名 |
Nakajima, Takero |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ymTNuNkh.html |
信州大学研究者総覧へのリンク |
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氏名 |
Kamijo, Yuji |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.gCTFuakh.html |
出版者 |
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出版者 |
WILEY-BLACKWELL PUBLISHING, INC |
引用 |
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内容記述 |
GENES TO CELLS. 15(2):91-100 (2010) |
書誌情報 |
GENES TO CELLS
巻 15,
号 2,
p. 91-100,
発行日 2010-02
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抄録 |
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内容記述 |
Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a member of the nuclear receptor family, regulating fatty acid degradation in many organs. Two-dimensional SDS-PAGE of brown adipose tissue (BAT) from PPAR alpha-null mice produced a higher-density spot. Proteomic analysis indicated that the protein was pyruvate dehydrogenase beta (PDH beta). To observe PDH beta regulation in BAT, the organ was stimulated by long-term cold exposure, and the activities of associated enzymes were investigated. Histological and biochemical analyses of BAT showed a significant decrease in the triglyceride content in wild-type mice and some degree of decrease in PPAR alpha-null mice on cold exposure. Analyses of molecules related to glucose metabolism showed that the expression of PDH beta is under PPAR alpha-specific regulation, and that glucose degradation ability may decrease on cold exposure. In contrast, analyses of molecules related to fatty acid metabolism showed that numerous PPAR alpha/gamma target molecules are induced on cold exposure, and that fatty acid degradation ability in wild-type mice is markedly enhanced and also increases to same degree in PPAR alpha-null mice on cold exposure. Thus, this study proposes novel and multiple roles of PPAR alpha in BAT. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
1356-9597 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA11078945 |
PubMed |
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関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20002497 |
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関連名称 |
20002497 |
権利 |
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権利情報 |
The definitive version is available at www3.intersience.wiley.com |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274177800001 |