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  1. 050 医学部, 大学院医学系研究科
  2. 0501 学術論文

Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia

http://hdl.handle.net/10091/15975
36abaa5d-8e6a-46e0-9778-92d46b85c040
名前 / ファイル ライセンス アクション
Aberrant_Expression_TFF1_TFF2_PDX1.pdf Aberrant_Expression_TFF1_TFF2_PDX1.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-09-21
タイトル
言語 en
タイトル Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia
言語
言語 eng
キーワード
主題Scheme Other
主題 Endocervix
キーワード
主題Scheme Other
主題 Human
キーワード
主題Scheme Other
主題 Keratan sulfate
キーワード
主題Scheme Other
主題 Lobular endocervical glandular hyperplasia
キーワード
主題Scheme Other
主題 Mucin
キーワード
主題Scheme Other
主題 Pancreatic-duodenal homeobox 1
キーワード
主題Scheme Other
主題 PDX1
キーワード
主題Scheme Other
主題 Trefoil factor family
キーワード
主題Scheme Other
主題 TFF
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ota, Hiroyoshi

× Ota, Hiroyoshi

WEKO 7453

en Ota, Hiroyoshi

Search repository
Harada, Oi

× Harada, Oi

WEKO 7454

en Harada, Oi

Search repository
Uehara, Takeshi

× Uehara, Takeshi

WEKO 7455

en Uehara, Takeshi

Search repository
Hayama, Masayoshi

× Hayama, Masayoshi

WEKO 7456

en Hayama, Masayoshi

Search repository
Ishii, Keiko

× Ishii, Keiko

WEKO 7457

en Ishii, Keiko

Search repository
信州大学研究者総覧へのリンク
氏名 Ota, Hiroyoshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html
信州大学研究者総覧へのリンク
氏名 Uehara, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyegpkh.html
出版者
出版者 AMER SOC CLINICAL PATHOLOGY
引用
内容記述タイプ Other
内容記述 AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 135(2):253-261 (2011)
書誌情報 AMERICAN JOURNAL OF CLINICAL PATHOLOGY

巻 135, 号 2, p. 253-261, 発行日 2011-02
抄録
内容記述タイプ Abstract
内容記述 Lobular endocervical glandular hyperplasia (LEGH) is a distinct benign glandular lesion expressing gastric gland mucous cell-type mucin (N-acetylglucosaminal -> 4galactose -> R [GlcNAc alpha 1 -> 4Gal -> R]). To investigate histogenesis and diagnostic markers of LEGH, we examined the immunohistochemical expression profile of gastric surface mucous cell (MUC5AC and TFF1), gastric gland mucous cell (MUC6, TFF2, and GlcNAc alpha 1 -> 4Gal -> R), gastric pyloric epithelial cell (PDX1), and endocervical cell (keratan sulfate) markers in normal endocervix samples and benign glandular lesions (nabothian cysts, tunnel clusters, and LEGHs). MUC5AC and MUC6 were expressed in normal endocervical mucosa and benign glandular lesions. TFF1, TFF2, GlcNAc alpha 1 -> 4Gal -> R, and PDX1 were expressed only in LEGH. Keratan sulfate was expressed in normal endocervical mucosa and benign glandular lesions. In LEGH, gastric surface mucous cell and gastric gland mucous cell differentiation were demonstrated, and transdifferentiation from endocervical mucosa into gastric pyloric mucosa was suggested. In addition to GlcNAc alpha 1 -> 4Gal -> R, TFF1, TFF2, and PDX1 are additional useful markers for LEGH.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ PISSN
収録物識別子 0002-9173
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00520469
PubMed
関連識別子
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/21228366
関連名称
関連名称 21228366
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1309/AJCPQMAO3PW4OGOF
関連名称
関連名称 10.1309/AJCPQMAO3PW4OGOF
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286452800009
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