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Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia
http://hdl.handle.net/10091/15975
http://hdl.handle.net/10091/1597536abaa5d-8e6a-46e0-9778-92d46b85c040
名前 / ファイル | ライセンス | アクション |
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Aberrant_Expression_TFF1_TFF2_PDX1.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-09-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Aberrant Expression of TFF1, TFF2, and PDX1 and Their Diagnostic Value in Lobular Endocervical Glandular Hyperplasia | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1309/AJCPQMAO3PW4OGOF | |||||
関連名称 | 10.1309/AJCPQMAO3PW4OGOF | |||||
キーワード | ||||||
主題 | Endocervix, Human, Keratan sulfate, Lobular endocervical glandular hyperplasia, Mucin, Pancreatic-duodenal homeobox 1, PDX1, Trefoil factor family, TFF | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ota, Hiroyoshi
× Ota, Hiroyoshi× Harada, Oi× Uehara, Takeshi× Hayama, Masayoshi× Ishii, Keiko |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Ota, Hiroyoshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.WNkCHhkh.html | |||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Uehara, Takeshi | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.jNyegpkh.html | |||||
出版者 | ||||||
出版者 | AMER SOC CLINICAL PATHOLOGY | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 135(2):253-261 (2011) | |||||
書誌情報 |
AMERICAN JOURNAL OF CLINICAL PATHOLOGY 巻 135, 号 2, p. 253-261, 発行日 2011-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lobular endocervical glandular hyperplasia (LEGH) is a distinct benign glandular lesion expressing gastric gland mucous cell-type mucin (N-acetylglucosaminal -> 4galactose -> R [GlcNAc alpha 1 -> 4Gal -> R]). To investigate histogenesis and diagnostic markers of LEGH, we examined the immunohistochemical expression profile of gastric surface mucous cell (MUC5AC and TFF1), gastric gland mucous cell (MUC6, TFF2, and GlcNAc alpha 1 -> 4Gal -> R), gastric pyloric epithelial cell (PDX1), and endocervical cell (keratan sulfate) markers in normal endocervix samples and benign glandular lesions (nabothian cysts, tunnel clusters, and LEGHs). MUC5AC and MUC6 were expressed in normal endocervical mucosa and benign glandular lesions. TFF1, TFF2, GlcNAc alpha 1 -> 4Gal -> R, and PDX1 were expressed only in LEGH. Keratan sulfate was expressed in normal endocervical mucosa and benign glandular lesions. In LEGH, gastric surface mucous cell and gastric gland mucous cell differentiation were demonstrated, and transdifferentiation from endocervical mucosa into gastric pyloric mucosa was suggested. In addition to GlcNAc alpha 1 -> 4Gal -> R, TFF1, TFF2, and PDX1 are additional useful markers for LEGH. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0002-9173 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00520469 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/21228366 | |||||
関連名称 | 21228366 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000286452800009 |