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ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現
http://hdl.handle.net/10091/9262
http://hdl.handle.net/10091/9262f827087a-ddca-4216-8d10-6ec444581c30
| 名前 / ファイル | ライセンス | アクション |
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Shinshu_Med47-5-04.pdf (361.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2010-03-24 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Expression of Endothelin-1 in the Inflamed Myocardium of an Experimental Autoimmune Myocarditis Rat Model | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | jpn | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | myocarditis, endothelin 心筋炎, エンドセリン |
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| 資源タイプ | ||||||||||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| タイプ | journal article | |||||||||||||
| 著者 |
矢嶋, 紀幸
× 矢嶋, 紀幸
× 鈴木, 淳一
× 北林, 浩
× 磯部, 光章
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| 出版者 | ||||||||||||||
| 出版者 | 信州医学会 | |||||||||||||
| 引用 | ||||||||||||||
| 内容記述 | 信州医学雑誌 47(5): 389-391(1999) | |||||||||||||
| 書誌情報 |
信州医学雑誌 巻 47, 号 5, p. 389-391, 発行日 1999-10-10 |
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| 抄録 | ||||||||||||||
| 内容記述 | Myocarditis is a potentially lethal inflammatory disease in humans.In this disease,large amounts of cytokines are released from inflammatory cells,which then stimulate endothelial cells to secrete endothelin-1 (ET-1). ET-1 has been isolated from endothelial cells and is a key mediator in several cardiovascular diseases. However, the immunological effects of ET-1 in myocarditis have not been reported.To investigate the roles of ET-1 expression in myocarditis, immunohistochemistry and reverse transcription-polymerase chain eaction (RT-PCR)were used to detect ET-1 in rat hearts with experimental autoimmune myocarditis (EAM). The EAM rat hearts were harvested at days 7,14,21 and 28 (n＝12).For the control study,hearts from rats without immunization were also harvested at day 28 (n＝5). Immunohistochemically, ET-1 was faintly expressed in unimmunized hearts.In EAM hearts,ET-1 expression was enhanced in the endothelial cells of small vasculatures in the myocardium at days 7 and 14.ET-1 was observed prior to interstitial cell infiltration and myocardial damage. However, ET-1 expression was decreased in the myocardium at days 21 and 28. Using RT-PCR,a single band corresponding to ET-1 was detected in unimmunized and EAM samples on days 7 to 28.In this study,ET-1 was enhanced in the early phase of EAM,and decreased in the chronic phase.ET-1 may therefore play a critical role in the early stage of EAM inflammation and may have diagnostic value in clinical myocarditis. | |||||||||||||
| 資源タイプ（コンテンツの種類） | ||||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 0037-3826 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AN00120815 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
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矢嶋, 紀幸, 鈴木, 淳一, 北林, 浩, 磯部, 光章, 1999, ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現: 信州医学会, 389–391 p.
