{"_buckets": {"deposit": "50ba4c9d-0eea-4743-b6c4-c5b5101957a2"}, "_deposit": {"id": "4373", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4373"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00004373", "sets": []}, "author_link": ["10352", "10353", "10354", "10355"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-10-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "391", "bibliographicPageStart": "389", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "信州医学雑誌"}]}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Myocarditis is a potentially lethal inflammatory disease in humans.In this disease,large amounts of cytokines are released from inflammatory cells,which then stimulate endothelial cells to secrete endothelin-1 (ET-1). ET-1 has been isolated from endothelial cells and is a key mediator in several cardiovascular diseases. However, the immunological effects of ET-1 in myocarditis have not been reported.To investigate the roles of ET-1 expression in myocarditis, immunohistochemistry and reverse transcription-polymerase chain eaction (RT-PCR)were used to detect ET-1 in rat hearts with experimental autoimmune myocarditis (EAM). The EAM rat hearts were harvested at days 7,14,21 and 28 (n＝12).For the control study,hearts from rats without immunization were also harvested at day 28 (n＝5). Immunohistochemically, ET-1 was faintly expressed in unimmunized hearts.In EAM hearts,ET-1 expression was enhanced in the endothelial cells of small vasculatures in the myocardium at days 7 and 14.ET-1 was observed prior to interstitial cell infiltration and myocardial damage. However, ET-1 expression was decreased in the myocardium at days 21 and 28. Using RT-PCR,a single band corresponding to ET-1 was detected in unimmunized and EAM samples on days 7 to 28.In this study,ET-1 was enhanced in the early phase of EAM,and decreased in the chronic phase.ET-1 may therefore play a critical role in the early stage of EAM inflammation and may have diagnostic value in clinical myocarditis.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ（コンテンツの種類）", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_31": {"attribute_name": "フォーマット：mimeタイプ", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "信州医学雑誌 47(5): 389-391(1999)", "subitem_description_type": "Other"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "信州医学会"}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0037-3826", "subitem_source_identifier_type": "PISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00120815", "subitem_source_identifier_type": "NCID"}]}, "item_6_text_66": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "04"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "矢嶋,  紀幸", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10352", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木,  淳一", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10353", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "北林,  浩", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10354", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "磯部,  光章", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10355", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Shinshu_Med47-5-04.pdf", "filesize": [{"value": "361.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 361500.0, "url": {"label": "Shinshu_Med47-5-04.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/4373/files/Shinshu_Med47-5-04.pdf"}, "version_id": "8f736028-38b6-4a68-bce3-9c7798d8a3cb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "myocarditis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endothelin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋炎", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エンドセリン", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現", "subitem_title_language": "ja"}, {"subitem_title": "Expression of Endothelin-1 in the Inflamed Myocardium of an Experimental Autoimmune Myocarditis Rat Model", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["558"], "permalink_uri": "http://hdl.handle.net/10091/9262", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2010-03-24"}, "publish_date": "2010-03-24", "publish_status": "0", "recid": "4373", "relation": {}, "relation_version_is_last": true, "title": ["ラット自己免疫性心筋炎モデル心内におけるエンドセリン-１の発現"], "weko_shared_id": -1}