Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2012-10-02 |
タイトル |
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タイトル |
IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice |
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言語 |
jpn |
DOI |
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関連識別子 |
https://doi.org/10.4049/jimmunol.1101561 |
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関連名称 |
10.4049/jimmunol.1101561 |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Yoshizawa, Katsumi
Nakajima, Shinsuke
Notake, Tsuyoshi
Miyagawa, Shin-Ichi
Hida, Shigeaki
Taki, Shinsuke
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信州大学研究者総覧へのリンク |
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氏名 |
Taki, Shinsuke |
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URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html |
出版者 |
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出版者 |
AMER ASSOC IMMUNOLOGISTS |
引用 |
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内容記述 |
JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011) |
書誌情報 |
JOURNAL OF IMMUNOLOGY
巻 187,
号 10,
p. 5162-5169,
発行日 2011-11-15
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内容記述 |
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内容記述 |
信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第910号)・好沢克 |
内容記述 |
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内容記述 |
Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc. |
抄録 |
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内容記述 |
In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-1767 |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00699656 |
PubMed |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21967894 |
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関連名称 |
21967894 |
権利 |
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権利情報 |
Copyright (C) 2011 The American Association of Immunologists, Inc. |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296767300025 |