WEKO3
アイテム
{"_buckets": {"deposit": "bbba8f81-b7d1-438a-91c8-55870ade0751"}, "_deposit": {"id": "7194", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "7194"}, "status": "published"}, "_oai": {"id": "oai:soar-ir.repo.nii.ac.jp:00007194", "sets": ["849"]}, "author_link": ["17456", "17457", "17458", "17459", "17460", "17461"], "item_1628147817048": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-11-15", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "5169", "bibliographicPageStart": "5162", "bibliographicVolumeNumber": "187", "bibliographic_titles": [{"bibliographic_title": "JOURNAL OF IMMUNOLOGY"}]}]}, "item_6_description_19": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第910号)・好沢克", "subitem_description_type": "Other"}, {"subitem_description": "Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc.", "subitem_description_type": "Other"}]}, "item_6_description_20": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169.", "subitem_description_type": "Abstract"}]}, "item_6_description_30": {"attribute_name": "資源タイプ(コンテンツの種類)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_6_description_5": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011)", "subitem_description_type": "Other"}]}, "item_6_link_3": {"attribute_name": "信州大学研究者総覧へのリンク", "attribute_value_mlt": [{"subitem_link_text": "Taki, Shinsuke", "subitem_link_url": "http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html"}]}, "item_6_link_67": {"attribute_name": "WoS", "attribute_value_mlt": [{"subitem_link_text": "Web of Science", "subitem_link_url": "http://gateway.isiknowledge.com/gateway/Gateway.cgi?\u0026GWVersion=2\u0026SrcAuth=ShinshuUniv\u0026SrcApp=ShinshuUniv\u0026DestLinkType=FullRecord\u0026DestApp=WOS\u0026KeyUT=000296767300025"}]}, "item_6_publisher_4": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "AMER ASSOC IMMUNOLOGISTS"}]}, "item_6_relation_47": {"attribute_name": "PubMed", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "21967894"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search\u0026DB=pubmed\u0026term=21967894", "subitem_relation_type_select": "PMID"}}]}, "item_6_relation_48": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.4049/jimmunol.1101561"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.4049/jimmunol.1101561", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_62": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright (C) 2011 The American Association of Immunologists, Inc."}]}, "item_6_select_64": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_6_source_id_35": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-1767", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_39": {"attribute_name": "NII ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-1767", "subitem_source_identifier_type": "ISSN"}]}, "item_6_source_id_40": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00699656", "subitem_source_identifier_type": "NCID"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yoshizawa, Katsumi"}], "nameIdentifiers": [{"nameIdentifier": "17456", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Shinsuke"}], "nameIdentifiers": [{"nameIdentifier": "17457", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Notake, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "17458", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyagawa, Shin-Ichi"}], "nameIdentifiers": [{"nameIdentifier": "17459", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hida, Shigeaki"}], "nameIdentifiers": [{"nameIdentifier": "17460", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taki, Shinsuke"}], "nameIdentifiers": [{"nameIdentifier": "17461", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2015-09-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "H23Kou910_Yoshizawa.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "H23Kou910_Yoshizawa.pdf", "url": "https://soar-ir.repo.nii.ac.jp/record/7194/files/H23Kou910_Yoshizawa.pdf"}, "version_id": "554ac04c-15b8-4b73-b730-15917622ccbd"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["849"], "permalink_uri": "http://hdl.handle.net/10091/16024", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2012-10-02"}, "publish_date": "2012-10-02", "publish_status": "0", "recid": "7194", "relation": {}, "relation_version_is_last": true, "title": ["IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice"], "weko_shared_id": -1}
IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice
http://hdl.handle.net/10091/16024
http://hdl.handle.net/10091/160248918413c-3a1e-4ef9-9916-a52e2fccc0e9
名前 / ファイル | ライセンス | アクション |
---|---|---|
H23Kou910_Yoshizawa.pdf (1.7 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-10-02 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice | |||||
言語 | ||||||
言語 | jpn | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.4049/jimmunol.1101561 | |||||
関連名称 | 10.4049/jimmunol.1101561 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yoshizawa, Katsumi
× Yoshizawa, Katsumi× Nakajima, Shinsuke× Notake, Tsuyoshi× Miyagawa, Shin-Ichi× Hida, Shigeaki× Taki, Shinsuke |
|||||
信州大学研究者総覧へのリンク | ||||||
氏名 | Taki, Shinsuke | |||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html | |||||
出版者 | ||||||
出版者 | AMER ASSOC IMMUNOLOGISTS | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011) | |||||
書誌情報 |
JOURNAL OF IMMUNOLOGY 巻 187, 号 10, p. 5162-5169, 発行日 2011-11-15 |
|||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第910号)・好沢克 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-1767 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00699656 | |||||
PubMed | ||||||
識別子タイプ | PMID | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21967894 | |||||
関連名称 | 21967894 | |||||
権利 | ||||||
権利情報 | Copyright (C) 2011 The American Association of Immunologists, Inc. | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296767300025 |