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  1. 050 医学部, 大学院医学系研究科
  2. 0507 学位論文
  3. 博士(医学)

IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice

http://hdl.handle.net/10091/16024
8918413c-3a1e-4ef9-9916-a52e2fccc0e9
名前 / ファイル ライセンス アクション
H23Kou910_Yoshizawa.pdf H23Kou910_Yoshizawa.pdf (1.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-10-02
タイトル
言語 ja
タイトル IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice
言語
言語 jpn
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yoshizawa, Katsumi

× Yoshizawa, Katsumi

WEKO 17456

Yoshizawa, Katsumi

Search repository
Nakajima, Shinsuke

× Nakajima, Shinsuke

WEKO 17457

Nakajima, Shinsuke

Search repository
Notake, Tsuyoshi

× Notake, Tsuyoshi

WEKO 17458

Notake, Tsuyoshi

Search repository
Miyagawa, Shin-Ichi

× Miyagawa, Shin-Ichi

WEKO 17459

Miyagawa, Shin-Ichi

Search repository
Hida, Shigeaki

× Hida, Shigeaki

WEKO 17460

Hida, Shigeaki

Search repository
Taki, Shinsuke

× Taki, Shinsuke

WEKO 17461

Taki, Shinsuke

Search repository
信州大学研究者総覧へのリンク
氏名 Taki, Shinsuke
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.OhnFjeyh.html
出版者
出版者 AMER ASSOC IMMUNOLOGISTS
引用
内容記述タイプ Other
内容記述 JOURNAL OF IMMUNOLOGY. 187(10):5162-5169 (2011)
書誌情報 JOURNAL OF IMMUNOLOGY

巻 187, 号 10, p. 5162-5169, 発行日 2011-11-15
内容記述
内容記述タイプ Other
内容記述 信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第910号)・好沢克
内容記述
内容記述タイプ Other
内容記述 Originally published in The Journal of Immunology. Yoshizawa, K; Nakajima, S; Notake, T; Miyagawa, SI; Hida, S; Taki, S. 2011. IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice . J. Immunol. Vol.187(10): pp5162-pp5169. Copyright (C) 2011 The American Association of Immunologists, Inc.
抄録
内容記述タイプ Abstract
内容記述 In mice lacking IL-15, NK cell development is arrested at immature stages, providing an opportunity to investigate the earliest developing NK cells that would respond to IL-15. We show in this study that immature NK cells were present in the spleen as well as bone marrow (BM) and contained IL-15-high-responder cells. Thus, mature NK cells were generated more efficiently from IL-15(-/-) than from control donor cells in radiation BM chimeras, and the rate of IL-15-induced cell division in vitro was higher in NK cells in the spleen and BM from IL-5(-/-) mice than in those from wild-type mice. Phenotypically, NK cells developed in IL-15(-/-) mice up to the minor but discrete CD11b(-)CD27(+)DX5(hi)CD51(dull)CD127(dull)CD122(hi) stage, which contained the majority of Ly49G2(+) and D+ NK cells both in the spleen and BM. Even among wild-type splenic NK cells, IL-15-induced proliferation was most prominent in CD11b(-)DX5(hi) cells. Notably, IL-15-mediated preferential expansion (but not conversion from Ly49(-) cells) of Ly49(+) NK cells was observed in vitro only for NK cells in the spleen. These observations indicated the uneven distribution of NK cells of different developing stages with variable IL-15 responsiveness in these lymphoid organs. Immature NK cells in the spleen may contribute, as auxiliaries to those in BM, to the mature NK cell compartment through IL-15-driven extramarrow expansion under steady-state or inflammatory conditions. The Journal of Immunology, 2011, 187: 5162-5169.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-1767
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00699656
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=21967894
関連名称
関連名称 21967894
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.4049/jimmunol.1101561
関連名称
関連名称 10.4049/jimmunol.1101561
権利
権利情報 Copyright (C) 2011 The American Association of Immunologists, Inc.
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
WoS
表示名 Web of Science
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000296767300025
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