Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2013-04-23 |
タイトル |
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タイトル |
Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term |
言語 |
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言語 |
eng |
DOI |
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関連識別子 |
https://doi.org/10.1248/bpb.33.249 |
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関連名称 |
10.1248/bpb.33.249 |
キーワード |
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主題 |
cytochrome P450 3A, fetal membrane, amnion, chorion, decidua, testosterone 6 beta-hydroxylation |
資源タイプ |
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資源 |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
著者 |
Maezawa, Kayoko
Matsunaga, Tamihide
Takezawa, Takashi
Kanai, Makoto
Ohira, Satoshi
Ohmori, Shigeru
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信州大学研究者総覧へのリンク |
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氏名 |
Kanai, Makoto |
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URL |
https://soar-rd.shinshu-u.ac.jp/profile/ja.WVnNupkh.html |
出版者 |
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出版者 |
PHARMACEUTICAL SOC JAPAN |
引用 |
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内容記述 |
BIOLOGICAL & PHARMACEUTICAL BULLETIN. 33(2):249-254 (2010) |
書誌情報 |
BIOLOGICAL & PHARMACEUTICAL BULLETIN
巻 33,
号 2,
p. 249-254,
発行日 2010-02
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抄録 |
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内容記述 |
Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6 beta-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CVP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs. |
資源タイプ(コンテンツの種類) |
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内容記述 |
Article |
ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0918-6158 |
書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10885497 |
権利 |
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権利情報 |
Copyright© 2010 The Pharmaceutical Society of Japan |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
WoS |
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URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274005600015 |