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Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term
http://hdl.handle.net/10091/16950
http://hdl.handle.net/10091/16950d51d96b0-0ac4-48ec-9221-411712b2dfe6
名前 / ファイル | ライセンス | アクション |
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Cytochrome_P450_3As_Gene_Expression_Testosterone.pdf (267.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cytochrome P450 3As Gene Expression and Testosterone 6 beta-Hydroxylase Activity in Human Fetal Membranes and Placenta at Full Term | |||||
言語 | ||||||
言語 | eng | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1248/bpb.33.249 | |||||
関連名称 | 10.1248/bpb.33.249 | |||||
キーワード | ||||||
主題 | cytochrome P450 3A, fetal membrane, amnion, chorion, decidua, testosterone 6 beta-hydroxylation | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Maezawa, Kayoko
× Maezawa, Kayoko× Matsunaga, Tamihide× Takezawa, Takashi× Kanai, Makoto× Ohira, Satoshi× Ohmori, Shigeru |
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信州大学研究者総覧へのリンク | ||||||
氏名 | Kanai, Makoto | |||||
URL | https://soar-rd.shinshu-u.ac.jp/profile/ja.WVnNupkh.html | |||||
出版者 | ||||||
出版者 | PHARMACEUTICAL SOC JAPAN | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | BIOLOGICAL & PHARMACEUTICAL BULLETIN. 33(2):249-254 (2010) | |||||
書誌情報 |
BIOLOGICAL & PHARMACEUTICAL BULLETIN 巻 33, 号 2, p. 249-254, 発行日 2010-02 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Expression levels of cytochrome P450 (CYP) 3A4, CYP3A5 and CYP3A7 mRNAs in placentas and fetal membranes, which were split into amnion and chorion leave attached decidua (chorion/decidua), obtained from pregnant women with normal delivery (5 subjects) and Caesarean section (15 subjects) were determined. These CYP3A mRNAs were also expressed in amnion and chorion/decidua together with placenta, although the expression level of these mRNAs was strikingly different between subjects. The expression level of the CYP3A4 mRNA in the placenta was about 2-fold higher than those in amnion and chorion/decidua. On the other hand, the expression levels of CYP3A5 and CYP3A7 mRNAs were highest in chorion/decidua. The immunologically related protein(s) with CYP3A7 was detected in all tissues examined. Testosterone 6 beta-hydroxylase activity in homogenate of human placenta, amnion and chorion/decidua were 26.6, 3.7 and 4.6 pmol/h/mg protein, respectively. These results suggest that CVP3As in fetal membranes have the metabolic function to protect the fetus from exposure to drugs. | |||||
資源タイプ(コンテンツの種類) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
権利 | ||||||
権利情報 | Copyright© 2010 The Pharmaceutical Society of Japan | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
WoS | ||||||
表示名 | Web of Science | |||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000274005600015 |