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  1. 070 農学部, 大学院農学研究科 (Faculty&Graduate School of Agriculture)
  2. 0701 学術論文 (Journal Articles)

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ

http://hdl.handle.net/10091/16134
051e06fd-feff-46a6-9966-8498761ac24e
プレビュー
名前 / ファイル ライセンス Actions
Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf (838.1 kB)
item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-10
タイトル
タイトル Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
言語
言語 eng
キーワード
主題 lacZ
キーワード
主題 ODN
キーワード
主題 regulatory T cell
キーワード
主題 Streptococcus thermophilus
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shimosato, Takeshi

× Shimosato, Takeshi

WEKO 32558

Shimosato, Takeshi

Search repository
Tohno, Masanori

× Tohno, Masanori

WEKO 32559

Tohno, Masanori

Search repository
Sato, Takashi

× Sato, Takashi

WEKO 32560

Sato, Takashi

Search repository
Nishimura, Junko

× Nishimura, Junko

WEKO 32561

Nishimura, Junko

Search repository
Kawai, Yasushi

× Kawai, Yasushi

WEKO 32562

Kawai, Yasushi

Search repository
Saito, Tadao

× Saito, Tadao

WEKO 32563

Saito, Tadao

Search repository
Kitazawa, Haruki

× Kitazawa, Haruki

WEKO 32564

Kitazawa, Haruki

Search repository
信州大学研究者総覧へのリンク
Shimosato, Takeshi
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述タイプ Other
内容記述 ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009)
書誌情報 ANIMAL SCIENCE JOURNAL

巻 80, 号 5, p. 597-604, 発行日 2009
抄録
内容記述タイプ Abstract
内容記述 Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds.
資源タイプ(コンテンツの種類)
内容記述タイプ Other
内容記述 Article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1344-3941
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11677214
PubMed
関連識別子
識別子タイプ PMID
関連識別子 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed&term=20163626
関連名称
関連名称 20163626
DOI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1111/j.1740-0929.2009.00680.x
関連名称
関連名称 10.1111/j.1740-0929.2009.00680.x
権利
権利情報 The definitive version is available at www.blackwell-synergy.com
著者版フラグ
値 author
WoS
Web of Science
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270310300015
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