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Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
http://hdl.handle.net/10091/16134
http://hdl.handle.net/10091/16134051e06fd-feff-46a6-9966-8498761ac24e
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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公開日 | 2012-12-10 | |||||||||||||||||||
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タイトル | Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ | |||||||||||||||||||
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言語 | eng | |||||||||||||||||||
DOI | ||||||||||||||||||||
関連識別子 | https://doi.org/10.1111/j.1740-0929.2009.00680.x | |||||||||||||||||||
関連名称 | 10.1111/j.1740-0929.2009.00680.x | |||||||||||||||||||
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主題 | lacZ, ODN, regulatory T cell, Streptococcus thermophilus | |||||||||||||||||||
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資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
タイプ | journal article | |||||||||||||||||||
著者 |
Shimosato, Takeshi
× Shimosato, Takeshi
× Tohno, Masanori
× Sato, Takashi
× Nishimura, Junko
× Kawai, Yasushi
× Saito, Tadao
× Kitazawa, Haruki
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信州大学研究者総覧へのリンク | ||||||||||||||||||||
氏名 | Shimosato, Takeshi | |||||||||||||||||||
URL | http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html | |||||||||||||||||||
出版者 | ||||||||||||||||||||
出版者 | WILEY-BLACKWELL PUBLISHING, INC | |||||||||||||||||||
引用 | ||||||||||||||||||||
内容記述 | ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009) | |||||||||||||||||||
書誌情報 |
ANIMAL SCIENCE JOURNAL 巻 80, 号 5, p. 597-604, 発行日 2009 |
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抄録 | ||||||||||||||||||||
内容記述 | Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds. | |||||||||||||||||||
資源タイプ(コンテンツの種類) | ||||||||||||||||||||
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収録物識別子タイプ | ISSN | |||||||||||||||||||
収録物識別子 | 1344-3941 | |||||||||||||||||||
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収録物識別子タイプ | NCID | |||||||||||||||||||
収録物識別子 | AA11677214 | |||||||||||||||||||
PubMed | ||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||
関連識別子 | https://pubmed.ncbi.nlm.nih.gov/20163626/ | |||||||||||||||||||
関連名称 | 20163626 | |||||||||||||||||||
権利 | ||||||||||||||||||||
権利情報 | The definitive version is available at www.blackwell-synergy.com | |||||||||||||||||||
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出版タイプ | AM | |||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||||
WoS | ||||||||||||||||||||
URL | http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270310300015 |