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  1. 070 農学部, 大学院農学研究科
  2. 0701 学術論文

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ

http://hdl.handle.net/10091/16134
http://hdl.handle.net/10091/16134
051e06fd-feff-46a6-9966-8498761ac24e
名前 / ファイル ライセンス アクション
Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf Identification_potent_immunostimulatory_oligodeoxynucleotide.pdf (838.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-10
タイトル
タイトル Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
言語
言語 eng
DOI
関連識別子 https://doi.org/10.1111/j.1740-0929.2009.00680.x
関連名称 10.1111/j.1740-0929.2009.00680.x
キーワード
主題 lacZ, ODN, regulatory T cell, Streptococcus thermophilus
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Shimosato, Takeshi

× Shimosato, Takeshi

Shimosato, Takeshi

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Tohno, Masanori

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Tohno, Masanori

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Sato, Takashi

× Sato, Takashi

Sato, Takashi

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Nishimura, Junko

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Nishimura, Junko

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Kawai, Yasushi

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Kawai, Yasushi

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Saito, Tadao

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Saito, Tadao

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Kitazawa, Haruki

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Kitazawa, Haruki

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信州大学研究者総覧へのリンク
氏名 Shimosato, Takeshi
URL http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html
出版者
出版者 WILEY-BLACKWELL PUBLISHING, INC
引用
内容記述 ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009)
書誌情報 ANIMAL SCIENCE JOURNAL

巻 80, 号 5, p. 597-604, 発行日 2009
抄録
内容記述 Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds.
資源タイプ(コンテンツの種類)
ISSN
収録物識別子タイプ ISSN
収録物識別子 1344-3941
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11677214
PubMed
識別子タイプ PMID
関連識別子 https://pubmed.ncbi.nlm.nih.gov/20163626/
関連名称 20163626
権利
権利情報 The definitive version is available at www.blackwell-synergy.com
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
WoS
URL http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270310300015
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