Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2012-12-10 |
タイトル |
|
|
タイトル |
Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ |
言語 |
|
|
言語 |
eng |
DOI |
|
|
|
関連識別子 |
https://doi.org/10.1111/j.1740-0929.2009.00680.x |
|
|
関連名称 |
10.1111/j.1740-0929.2009.00680.x |
キーワード |
|
|
主題 |
lacZ, ODN, regulatory T cell, Streptococcus thermophilus |
資源タイプ |
|
|
資源 |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
journal article |
著者 |
Shimosato, Takeshi
Tohno, Masanori
Sato, Takashi
Nishimura, Junko
Kawai, Yasushi
Saito, Tadao
Kitazawa, Haruki
|
信州大学研究者総覧へのリンク |
|
|
氏名 |
Shimosato, Takeshi |
|
URL |
http://soar-rd.shinshu-u.ac.jp/profile/ja.ONLCjFkV.html |
出版者 |
|
|
出版者 |
WILEY-BLACKWELL PUBLISHING, INC |
引用 |
|
|
内容記述 |
ANIMAL SCIENCE JOURNAL. 80(5):597-604 (2009) |
書誌情報 |
ANIMAL SCIENCE JOURNAL
巻 80,
号 5,
p. 597-604,
発行日 2009
|
抄録 |
|
|
内容記述 |
Immunostimulatory sequences of oligodeoxynucleotides (ODNs), such as CpG ODNs, are potent stimulators of innate immunity. Here, we identified a strong immunostimulatory CpG ODN, which we named MsST, from the lac Z gene of Streptococcus (S.) thermophilus ATCC19258, and we evaluated its immune functions. In in vitro studies, MsST had a similar ability as the murine prototype CpG ODN 1555 to induce inflammatory cytokine production and cell proliferation. In mouse splenocytes, MsST increased the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells. We also analyzed the effects of MsST on the expression of regulatory cytokines by real-time quantitative PCR. MsST was more potent at inducing interleukin-10 expression than the ODN control 1612, indicating that MsST can augment the regulatory T cell response via Toll-like receptor 9, which plays an important role in suppressing T helper type 2 responses. These results suggest that S. thermophilus, whose genes include a strong Immunostimulatory sequence-ODN, is a good candidate for a starter culture to develop new physiologically functional foods and feeds. |
資源タイプ(コンテンツの種類) |
|
|
内容記述 |
Article |
ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1344-3941 |
書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11677214 |
PubMed |
|
|
|
関連識別子 |
https://pubmed.ncbi.nlm.nih.gov/20163626/ |
|
|
関連名称 |
20163626 |
権利 |
|
|
権利情報 |
The definitive version is available at www.blackwell-synergy.com |
出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
WoS |
|
|
URL |
http://gateway.isiknowledge.com/gateway/Gateway.cgi?&GWVersion=2&SrcAuth=ShinshuUniv&SrcApp=ShinshuUniv&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000270310300015 |